-
Article
Open AccessCSTF3 contributes to platinum resistance in ovarian cancer through alternative polyadenylation of lncRNA NEAT1 and generating the short isoform NEAT1_1
Platinum-based chemotherapy is the standard postoperative adjuvant treatment for ovarian cancer (OC). Despite the initial response to chemotherapy, 85% of advanced OC patients will have recurrent disease. Rela...
-
Article
Open AccessA potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer
The Hendra and Nipah viruses (HNVs) are highly pathogenic pathogens without approved interventions for human use. In addition, the interaction pattern between the attachment (G) and fusion (F) glycoproteins re...
-
Article
Open AccessBiomimetic chiral hydrogen-bonded organic-inorganic frameworks
Assembly ubiquitously occurs in nature and gives birth to numerous functional biomaterials and sophisticated organisms. In this work, chiral hydrogen-bonded organic-inorganic frameworks (HOIFs) are synthesized...
-
Article
Open AccessIdentification of Fangjihuangqi Decoction as a late-stage autophagy inhibitor with an adjuvant anti-tumor effect against non-small cell lung cancer
Clinically, although chemotherapy is one of the most commonly used methods of treating tumors, chemotherapeutic drugs can induce autophagic flux and increase tumor cell resistance, leading to drug tolerance. T...
-
Article
Open AccessImproved pea reference genome and pan-genome highlight genomic features and evolutionary characteristics
Complete and accurate reference genomes and annotations provide fundamental resources for functional genomics and crop breeding. Here we report a de novo assembly and annotation of a pea cultivar ZW6 with cont...
-
Article
Distribution characteristics and factors influencing microbial communities in the core soils of a seawater intrusion area in Longkou City, China
Microbes live throughout the soil profile. Microbial communities in subsurface horizons are impacted by a saltwater–freshwater transition zone formed by seawater intrusion (SWI) in coastal regions. The main pu...
-
Article
Open AccessSemen Ziziphi Spinosae attenuates blood–brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway
Semen Ziziphi Spinosae (SZS) has been extensively used in the daily diet as a functional food for neuroprotective health-benefit in China for many years. However, the neuroprotective mechanism of SZS associate...
-
Article
Clinical effectiveness of adjunctive diode laser on scaling and root planing in the treatment of periodontitis: is there an optimal combination of usage mode and application regimen? A systematic review and meta-analysis
This review aims to evaluate the adjunctive clinical effectiveness of diode laser (DL) to scaling and root planing (SRP) in the treatment of periodontitis, and identify the optimal combination of usage mode an...
-
Article
Open AccessCalculation model for ventilation friction resistance coefficient by surrounding rock roughness distribution characteristics of mine tunnel
Real-time mine ventilation network solution is the core way to realize the actual intelligent ventilation, and ventilation friction resistance coefficient is a significant parameter of network solution. With t...
-
Chapter and Conference Paper
Res-LSTM Infrared Image Fault Identification Method Based on Improved BEMD Frequency Domain Decomposition
Aiming at the problem of low accuracy of fault identification due to poor feature extraction ability of existing fault identification methods for infrared images of electrical equipment, a fault identification...
-
Article
Development and application of the Faba_bean_130K targeted next-generation sequencing SNP genoty** platform based on transcriptome sequencing
Large-scale faba bean transcriptome data are available, and the first genoty** platform based on liquid-phase probe targeted capture technology was developed for genetic and molecular breeding studies.
-
Article
Open AccessA new class of nonlinear Gronwall–Bellman delay integral inequalities with power and its applications
In this paper, we establish some new delay Gronwall–Bellman integral inequalities with power, which can be used as a convenient tool to study the qualitative properties of solutions to differential and integra...
-
Article
Open AccessCombining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model
Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/ne...
-
Article
Improved thermal stability of melamine resin spheres and electrochemical properties of their carbon derivatives induced by F127
Melamine–formaldehyde (MF) resin-based carbon stands out among energy materials due to their superior nitrogen content and intriguing comprehensive properties; however, the inferior rate capability hinders its...
-
Article
The influence of soil drought stress on the leaf transcriptome of faba bean (Vicia faba L.) in the Qinghai–Tibet Plateau
Water deficit has a significant impact on growth, development and yield of fava bean (Vicia fava L.) in arid and semi-arid climates. The aim of this study was to identify differentially expressed genes in the Qin...
-
Chapter and Conference Paper
Correlation Analysis of Chinese Pork Concept Stocks Based on Big Data
This article conducts an empirical study on the correlation between Chinese pork price and the fluctuation of the pork concept index. The first is to use Tushare financial data interface, crawler tools and oth...
-
Article
Open AccessDrought stress impact on leaf proteome variations of faba bean (Vicia faba L.) in the Qinghai–Tibet Plateau of China
Water scarcity is a major abiotic stress factor that strongly influences growth, development and yield of grain legumes in arid and semi-arid area of the world. Drought stress frequently occurs during the seed...
-
Article
MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma
Glioblastoma multiforme (GBM) is the most common and highly malignant primary brain tumor, which is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. To develop novel therape...
-
Article
Structure and function of seed storage proteins in faba bean (Vicia faba L.)
The protein subunit is the most important basic unit of protein, and its study can unravel the structure and function of seed storage proteins in faba bean. In this study, we identified six specific protein su...
-
Article
Open AccessUpregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation
Atrial Fibrillation (AF) is common in the elderly and Sestrins (Sesns) have been suggested to prevent age-related pathologies. The aim of this study was to investigate the effects of Sesns in AF. Clinical data...
