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Article
Development of a time-resolved immunochromatographic test strip for rapid and quantitative determination of retinol-binding protein 4 in urine
Urine retinol-binding protein 4 (RBP4) has recently been reported as a novel earlier biomarker of chronic kidney disease (CKD) which is a global public health problem with high morbidity and mortality. Accurat...
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Article
Tangeretin Attenuates Cerebral Ischemia–Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2
Pyroptosis is closely involved in the pathopoiesis of cerebral ischemia and reperfusion (I/R) injury which seriously dangers human’s life. Studies report that tangeretin (TANG), which is enriched in the peel of C...
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Chapter and Conference Paper
Research on Multi-model Hierarchical Optimization Design Technology for Railway Body Structure
Rapid advancements in design, structure, materials, and manufacturing technologies have significantly enhanced the performance metrics of railcar bodies. Amidst the increasing prominence of urban rail transit,...
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Article
Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis
NLRP3 inflammasome-mediated pyroptosis of macrophage acts essential roles in the progression of sepsis-induced acute lung injury (ALI). Tangeretin (TAN), enriched in citrus fruit peel, presents anti-oxidative ...
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Article
Open AccessOsteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate
Magnesium oxychloride cement has good mechanical properties, but poor water resistance.
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Article
Open AccessFTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA
Parkinson's disease (PD), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment...
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Article
Open AccessA HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway
Human epidermal growth factor receptor 2 (HER2) is a protein that is overexpressed in some types of cancer, including breast and urothelial cancer. Here we found that HER2 was present in a portion of colon can...
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Article
Vibration and far-field sound radiation of a horizontal, finite-long cylindrical shell partially submerged in fluid
The vibroacoustic study of a horizontal, finite-long cylindrical shell partially submerged in a fluid is presented in this paper. First, the mathematical and physical model of the system is established using t...
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Article
Open AccessMultiparameter prediction model of immune checkpoint inhibitors combined with chemotherapy for non-small cell lung cancer based on support vector machine learning
The reliable predictive markers to identify which patients with advanced non-small cell lung cancer tumors (NSCLC) will achieve durable clinical benefit (DCB) for chemo-immunotherapy are needed. In this retros...
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Article
Open AccessRNA binding proteins are potential novel biomarkers of egg quality in yellow catfish
Egg quality is a major concern in fish reproduction and development. An effective evaluation of egg quality prior to fertilization is helpful in improving the fertilization rate and survival rate of the larva....
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Article
Open AccessEfficacy and toxicity of Iodine-125 seed implantation for lymph node recurrence secondary to esophageal cancer after radiotherapy: a multicenter retrospective study
This multicenter study aimed to explore the efficacy and toxicity of radioactive Iodine-125 seed implantation for lymph node recurrence in patients with esophageal cancer after external radiotherapy.
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Article
Acoustic performance of near-rail low-height noise barriers installed on suburban railway bridges
With the large-scale construction of suburban railway viaducts, the noise problem along the viaducts is becoming more and more prominent. Conventional vertical noise barriers have been widely used to alleviate...
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Article
Open AccessSequencing introduced false positive rare taxa lead to biased microbial community diversity, assembly, and interaction interpretation in amplicon studies
Increasing studies have demonstrated potential disproportionate functional and ecological contributions of rare taxa in a microbial community. However, the study of the microbial rare biosphere is hampered by ...
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Article
Continuous monitoring system of gob temperature and its application
Due to the concealment of the fire source in the gob, the fire prevention and extinguishing work in the gob is facing great difficulties. This study is made in order to realize the real-time monitoring of gob ...
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Article
A comprehensive method to prevent top-coal spontaneous combustion utilizing dry ice as a fire extinguishing medium: test apparatus development and field application
There is a high potential for coal spontaneous combustion (CSC) above the roof beams of supports during the mining-stopped period. Early detection of temperature abnormal zones and corresponding measures are n...
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Article
Open AccessTargeting chondrocytes for arresting bony fusion in ankylosing spondylitis
Bony fusion caused by pathological new bone formation manifests the clinical feature of ankylosing spondylitis (AS). However, the underlying mechanism remains elusive. Here we discovered spontaneous kyphosis, ...
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Article
Osteomodulin is a Potential Genetic Target for Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is one of the most common genetic heart diseases. Its features include abnormal cardiomyocyte hypertrophy, microvascular dysfunction, and increased accumulation of intercellul...
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Article
Open AccessHhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells
Hhex(human hematopoietically expressed homeobox), also known as PRH, is originally considered as a transcription factor to regulate gene expression due to its homebox domain. Increasing studies show that Hhex ...
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Article
Selective targeting of the androgen receptor-DNA binding domain by the novel antiandrogen SBF-1 and inhibition of the growth of prostate cancer cells
Prostate cancers are reliant on androgens for growth and survival. Clinicians and researchers are looking for potent treatments for the resistant forms of prostate cancer; however, a handful of small molecules...
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Article
Revealing an Invasion Risk of Fish Species in Qingdao Underwater World by Environmental DNA Metabarcoding
Environmental DNA (eDNA) metabarcoding has emerged as a potentially powerful tool to monitor invasive fish species. As an alternative (or complementary) tool for biodiversity monitoring, eDNA metabarcoding had...
