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Open AccessCombined pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts survival and prognosis in patients with non-metastatic nasopharyngeal carcinoma: a retrospective study
The clinical significance of the combination of neutrophil–lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is unclear. This study investigated the predictive value of pretreatment NLR (pre-NLR) comb...
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Article
Open AccessIn Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug
A multifactorial and oriented scaffolds was constructed to stimulate osteochondral regeneration.
This is the first demonstr...
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Article
Open AccessA distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS
Numerous genes, including SOD1, mutated in familial and sporadic amyotrophic lateral sclerosis (f/sALS) share a role in DNA damage and repair, emphasizing genome disintegration in ALS. One possible outcome of chr...
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Article
Open AccessA single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization
The six species of lungfish possess both lungs and gills and are the closest extant relatives of tetrapods. Here, we report a single-cell transcriptome atlas of the West African lungfish (Protopterus annectens). ...
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Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal
Female-to-male sex reversals (pseudomales) are common in lower vertebrates and have been found in natural populations, which is a concern under rapid changes in environmental conditions. Pseudomales can exhibi...
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Article
Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization
Due to their broad functional plasticity, myeloid cells contribute to both liver injury and recovery during acetaminophen overdose-induced acute liver injury (APAP-ALI). A comprehensive understanding of cellul...
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Article
Open AccessEfficacy of concurrent chemoradiotherapy plus Endostar compared with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma: a retrospective study
To retrospectively analyze the efficacy and safety of concurrent chemoradiotherapy (CCRT) plus recombinant human endostatin (Endostar, CCRT + E) versus CCRT alone in locally advanced nasopharyngeal carcinoma (...
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Article
Open AccessA new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling
Restenosis after angioplasty is a major challenge for the treatment of coronary artery diseases. Facilitation of vascular smooth muscle cell (VSMC) apoptosis may be an attractive approach to decrease the incid...
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Article
EFFECT OF MONTMORILLONITE LAYER CHARGE ON THE THERMAL STABILITY OF BENTONITE
The thermal stability of bentonite is vitally important for its application in the casting field and the layer charge of montmorillonite (Qm) is one of its central crystal-chemical parameters. As the main compone...
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Article
Preparation and Visible Photocatalytic Properties of N-Doped TiO2/Muscovite Nanocomposites
As a photocatalyst with good prospects, TiO2 has the shortcomings of easy agglomeration and no catalytic performance under visible light. The purpose of the present study was to help solve these problems by emplo...
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Open AccessRosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities
Atherosclerosis is a chronic vascular disease posing a great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit lipid accumulation and polarization co...
