13 Result(s)

Article

Reply to: The G protein preference of orexin receptors is currently an unresolved issue

Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman… in Nature Communications (2023)

Article

Molecular mechanism of the wake-promoting agent TAK-925

The OX₂ orexin receptor (OX₂R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in humans. Antagonism of OX₂R is a proven therapeutic strategy ...

Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman… in Nature Communications (2022)

Article

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins

We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant...

Somnath Mukherjee, Satchal K. Erramilli, Mark Ammirati… in Nature Communications (2020)

Article

Structure of formylpeptide receptor 2-G_i complex reveals insights into ligand recognition and signaling

Formylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, FPRs, especi...

Youwen Zhuang, Heng Liu, X. Edward Zhou, Ravi Kumar Verma… in Nature Communications (2020)

Article

Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

In the PDF version of this Article, owing to a typesetting error, an incorrect figure was used for Extended Data Fig. 5; the correct figure was used in the HTML version. This has been corrected online.

Yanyong Kang, Oleg Kuybeda, Parker W. de Waal, Somnath Mukherjee, Ned Van Eps… in Nature (2018)

Article

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio

Mutations in the amyloid precursor protein (APP) gene and the aberrant cleavage of APP by γ-secretase are associated with Alzheimer’s disease (AD). Here we have developed a simple and sensitive cell-based assay t...

Ting-Hai Xu, Yan Yan, Yanyong Kang, Yi Jiang, Karsten Melcher, H Eric Xu in Cell Discovery (2016)

Article

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex

Serial femtosecond X-ray crystallography (SFX) using an X-ray free electron laser (XFEL) is a recent advancement in structural biology for solving crystal structures of challenging membrane proteins, including...

X. Edward Zhou, **ang Gao, Anton Barty, Yanyong Kang, Yuanzheng He… in Scientific Data (2016)

Article

Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3

Strigolactones (SLs) are endogenous hormones and exuded signaling molecules in plant responses to low levels of mineral nutrients. Key mediators of the SL signaling pathway in rice include the α/β-fold hydrola...

Li-Hua Zhao, X Edward Zhou, Wei Yi, Zhongshan Wu, Yue Liu, Yanyong Kang… in Cell Research (2015)

Article

Knockdown of CD146 reduces the migration and proliferation of human endothelial cells

Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear. Here we have for t...

Yanyong Kang, Fengcai Wang, **g Feng, Dongling Yang, Xu Yang, **yun Yan in Cell Research (2006)