3 Result(s)

Article

Reply to: The G protein preference of orexin receptors is currently an unresolved issue

Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman… in Nature Communications (2023)

Article

Molecular mechanism of the wake-promoting agent TAK-925

The OX₂ orexin receptor (OX₂R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in humans. Antagonism of OX₂R is a proven therapeutic strategy ...

Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman… in Nature Communications (2022)

Article

Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor

About 50% of the world’s arable land is strongly acidic (pH ≤ 5). The low pH solubilizes root-toxic ionic aluminium (Al³⁺) species from clay minerals, driving the evolution of counteractive adaptations in cultiva...

Rupak Doshi, Aaron P. McGrath, Miguel Piñeros, Paul Szewczyk… in Scientific Reports (2017)