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Article
Electron Microscopic Map** of Mitochondrial Morphology in the Cochlear Nerve Fibers
To enable nervous system function, neurons are powered in a use-dependent manner by mitochondria undergoing morphological-functional adaptation. In a well-studied model system—the mammalian cochlea, auditory n...
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Article
Harnessing the deep learning power of foundation models in single-cell omics
Foundation models hold great promise for analyzing single-cell omics data, yet various challenges remain that require further advancements. In this Comment, we discuss the progress, limitations and best practi...
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Open AccessAre Disaster Impact Estimates Distorted by Errors in Popular Night-Time Lights Data?
Satellite-detected night lights data are widely used to evaluate economic impacts of disasters. Growing evidence from elsewhere in applied economics suggests that impact estimates are potentially distorted whe...
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Open AccessMechanistic insights into 125I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2
Cholangiocarcinoma (CCA) is a rare tumor with a poor prognosis and poses significant therapeutic challenges. Herein, we investigated the mechanism of efficacy of 125I seed implantation therapy in CCA, focusing on...
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Open AccessPenpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study
Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining effi...
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Article
Open AccessDirect radical functionalization of native sugars
Naturally occurring (native) sugars and carbohydrates contain numerous hydroxyl groups of similar reactivity1,2. Chemists, therefore, rely typically on laborious, multi-step protecting-group strategies3 to conver...
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Open AccessHighly accurate carbohydrate-binding site prediction with DeepGlycanSite
As the most abundant organic substances in nature, carbohydrates are essential for life. Understanding how carbohydrates regulate proteins in the physiological and pathological processes presents opportunities...
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Article
Open AccessAltered chromatin topologies caused by balanced chromosomal translocation lead to central iris hypoplasia
Despite the advent of genomic sequencing, molecular diagnosis remains unsolved in approximately half of patients with Mendelian disorders, largely due to unclarified functions of noncoding regions and the diff...
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Article
Punching Shear Performance of Reinforced Concrete Slab-Column Joints with Shearhead Reinforcement
The punching shear performance of reinforced concrete (RC) slab–column joints with shearhead reinforcement was investigated to optimize shearhead reinforcement design. Nine slab–column joint specimens were des...
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Open AccessThe role of triglyceride-glucose index in the differential diagnosis of atherosclerotic stroke and cardiogenic stroke
This study aims to investigate the role of the triglyceride glucose (TyG) index in differentiating cardiogenic stroke (CE) from large atherosclerotic stroke (LAA).
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Article
Open AccessStructural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor
The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeosta...
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Open AccessEffect of liver transplants with retrograde reperfusion on early postoperative recovery of liver function and its risk factors
The purpose of this study was to investigate effect of liver Transplants (LT) with retrograde reperfusion on early postoperative recovery of liver function and its risk factors.
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Article
Histological Features of Uterine Myometrial Dysfunction: Possible Involvement of Localized Inflammation
The latest perspective suggests that elevated levels of inflammation and cytokines are implicated in atonic postpartum hemorrhage. Lipopolysaccharide (LPS) has been widely used to induce inflammation in animal...
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Article
AENet: attention enhancement network for industrial defect detection in complex and sensitive scenarios
Conventional image processing and machine learning based on handcrafted features struggle to meet the real time and high-accuracy requirements for industrial defect detection in complex, sensitive, and dynamic...
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Article
A photosynthetically active radiative cooling film
The sequestration of atmospheric CO2 through plant photosynthesis helps to mitigate climate change while providing other ecological benefits. However, heat and drought stress can limit plant growth and thus the m...
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Article
Dimerization and antidepressant recognition at noradrenaline transporter
The noradrenaline transporter has a pivotal role in regulating neurotransmitter balance and is crucial for normal physiology and neurobiology1. Dysfunction of noradrenaline transporter has been implicated in nume...
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Open AccessSeed germination ecology of endangered plant Horsfieldia hainanensis Merr. In China
Horsfieldia hainanensis Merr., an indicator species of China’s humid tropical rainforests, is endangered due to difficulties with population regeneration. In this study, the biological characteristics and germina...
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Open AccessSpatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...
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Article
Open AccessGenetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders
Psychiatric disorders are highly heritable yet polygenic, potentially involving hundreds of risk genes. Genome-wide association studies have identified hundreds of genomic susceptibility loci with susceptibili...
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Open AccessCorrelation of gasdermin B staining patterns with prognosis, progression, and immune response in colorectal cancer
Pyroptosis is a type of programmed cell death mediated by the gasdermin family. Gasdermin B (GSDMB), as a member of gasdermin family, can promote the occurrence of cell pyroptosis. However, the correlations of...
