26 Result(s)

Article

Structural basis of ligand recognition and design of antihistamines targeting histamine H₄ receptor

The histamine H₄ receptor (H₄R) plays key role in immune cell function and is a highly valued target for treating allergic and inflammatory diseases. However, structural information of H₄R remains elusive. Here, ...

Ruixue **a, Shuang Shi, Zhenmei Xu, Henry F. Vischer… in Nature Communications (2024)

Article

Identification of oleic acid as an endogenous ligand of GPR3

Although GPR3 plays pivotal roles in both the nervous system and metabolic processes, such as cold-induced thermogenesis, its endogenous ligand remains elusive. Here, by combining structural approach (includin...

Yangjie **ong, Zhenmei Xu, **nzhi Li, Yuqin Wang, **g Zhao, Na Wang… in Cell Research (2024)

Article

Structural basis of Sphingosine-1-phosphate transport via human SPNS2

Yaning Duan, Nancy C. P. Leong, **g Zhao, Yu Zhang, Dat T. Nguyen… in Cell Research (2024)

Article

Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation

Lysophosphatidylserine (LysoPS) is a lipid mediator that induces multiple cellular responses through binding to GPR174. Here, we present the cryo-electron microscopy (cryo-EM) structure of LysoPS-bound human G...

Jiale Liang, Asuka Inoue, Tatsuya Ikuta, Ruixue **a, Na Wang… in Nature Communications (2023)

Article

Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets for various diseases. aGPCRs are also known to be capable of self-activation via an autoproteolysis pr...

**nyan Zhu, Yu Qian, **aowan Li, Zhenmei Xu, Ruixue **a, Na Wang… in Nature Communications (2022)

Article

Structural basis of leukotriene B4 receptor 1 activation

Leukotriene B4 receptor 1 (BLT1) plays crucial roles in the acute inflammatory responses and is a valuable target for anti-inflammation treatment, however, the mechanism by which leukotriene B4 (LTB4) activate...

Na Wang, **nheng He, **g Zhao, Hualiang Jiang, ** Cheng, Yu **a… in Nature Communications (2022)

Article

Author Correction: Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism

Zhenmei Xu, Tatsuya Ikuta, Kouki Kawakami, Ryoji Kise, Yu Qian… in Nature Chemical Biology (2022)

Article

Cryo-EM structure of the human histamine H₁ receptor/G_q complex

Histamine receptors play important roles in various pathophysiological conditions and are effective targets for anti-allergy treatment, however the mechanism of receptor activation remain elusive. Here, we pre...

Ruixue **a, Na Wang, Zhenmei Xu, Yang Lu, **g Song, Anqi Zhang… in Nature Communications (2021)

Article

Crystal structure of heliorhodopsin 48C12

Yang Lu, X. Edward Zhou, **ang Gao, Na Wang, Ruixue **a, Zhenmei Xu… in Cell Research (2020)

Article

Ginkgolic acid, a sumoylation inhibitor, promotes adipocyte commitment but suppresses adipocyte terminal differentiation of mouse bone marrow stromal cells

Sumoylation is a post-translational modification process having an important influence in mesenchymal stem cell (MSC) differentiation. Thus, sumoylation-modulating chemicals might be used to control MSC differ...

Huadie Liu, Jianshuang Li, Di Lu, Jie Li, Minmin Liu, Yuanzheng He… in Scientific Reports (2018)

Article

Molecular assembly of rhodopsin with G protein-coupled receptor kinases

G protein-coupled receptor kinases (GRKs) play pivotal roles in desensitizing GPCR signaling but little is known about how GRKs recognize and phosphorylate GPCRs due to the technical difficulties in detecting ...

Yuanzheng He, **ang Gao, Devrishi Goswami, Li Hou, Kuntal Pal, Yanting Yin… in Cell Research (2017)

Article

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex

Serial femtosecond X-ray crystallography (SFX) using an X-ray free electron laser (XFEL) is a recent advancement in structural biology for solving crystal structures of challenging membrane proteins, including...

X. Edward Zhou, **ang Gao, Anton Barty, Yanyong Kang, Yuanzheng He… in Scientific Data (2016)

Article

Erratum: Discovery of a highly potent glucocorticoid for asthma treatment

Correction to: Cell Discovery (2015) 1, 15035; doi:10.1038/celldisc.2015.35; published online 15 December 2015 In the initial published version of this article, an error was made when we drew the chemical stru...

Yuanzheng He, **g**g Shi, Wei Yi, **n Ren, **ang Gao, Jianshuang Li… in Cell Discovery (2016)

Article

Discovery of a highly potent glucocorticoid for asthma treatment

Glucocorticoids are the most effective treatment for asthma. However, their clinical applications are limited by low efficacy in severe asthma and by undesired side effects associated with high dose or prolong...

Yuanzheng He, **g**g Shi, Wei Yi, **n Ren, **ang Gao, Jianshuang Li… in Cell Discovery (2015)