-
Article
Toward a solid microneedle patch for rapid and enhanced local analgesic action
Analgesic creams find widespread application as adjuncts for localized anesthesia prior to surgical procedures. Nevertheless, the onset of analgesic action is protracted due to the skin barrier’s inherent char...
-
Article
Towards integrated textile display systems
We receive approximately 80% of our external environmental information through vision, making display technology an essential component of modern life. The evolution of device structures has led to the iterati...
-
Article
Open AccessSilencing LINC00987 ameliorates adriamycin resistance of acute myeloid leukemia via miR-4458/HMGA2 axis
Most patients with acute myeloid leukemia (AML) eventually develop drug resistance, leading to a poor prognosis. Dysregulated long gene non coding RNAs (lincRNAs) have been implicated in chemoresistance in AML...
-
Article
Design and Implementation of Closed-Loop Control of Vector Force in Static Push-the-bit Rotary Steering System
Rotary steering systems (RSSs) have been increasingly used to develop horizontal wells. A static push-the-bit RSS uses three hydraulic modules with varying degrees of expansion and contraction to achieve chang...
-
Article
Open AccessGenomic investigation of Salmonella enterica Serovar Welikade from a pediatric diarrhea case first time in Shanghai, China
Salmonella, an important foodborne pathogen, was estimated to be responsible for 95.1 million cases and 50,771 deaths worldwide. Sixteen serovars were responsible for approximately 80% of Salmonella infections in...
-
Article
Novel low-temperature continuous phase-transition extraction process for efficient peanut oil production
Peanut oil is a traditional edible oil in China, and its oil yield and quality require improvement. In this study, the effects of different extraction techniques on the physicochemical properties, fatty acid c...
-
Article
Open AccessHydrogen peroxide is required for light-induced stomatal opening across different plant species
Stomatal movement is vital for plants to exchange gases and adaption to terrestrial habitats, which is regulated by environmental and phytohormonal signals. Here, we demonstrate that hydrogen peroxide (H2O2) is r...
-
Article
Open AccessDevelopment, validation and visualization of a web-based nomogram for predicting risk of new-onset diabetes after percutaneous coronary intervention
Simple and practical tools for screening high-risk new-onset diabetes after percutaneous coronary intervention (PCI) (NODAP) are urgently needed to improve post-PCI prognosis. We aimed to evaluate the risk fac...
-
Article
Open AccessWnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRN...
-
Article
Rational design and energy catalytic application of high-loading single-atom catalysts
It is well known that single-atom catalysts (SACs) have become a hot topic in the field of catalysis due to their advantages such as 100% metal atom utilization efficiency, high catalytic activity and selectiv...
-
Article
Open AccessThe early career resilience experience of generation Z newly graduated registered nurses in standardized training in the emergency department: a qualitative study in Shanghai
The period of standardized training is a transitional stage when Generation Z newly graduated registered nurses (Gen Z NGRNs) change their role from student to nurse. Affected by the COVID-19, they lack clinic...
-
Article
Robust Fiber Strain Sensor by Designing Coaxial Coiling Structure with Mutual Inductance Effect
Fiber strain sensors with robust sensing performance are indispensable for human–machine interactions in the electronic textiles. However, current fiber strain sensors are confronted with the challenges of una...
-
Article
Open AccessGLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma
While previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to discover if GLUT1 promotes tumor progression through a non-metabolic pathway.
-
Article
Båth’s Law Derived from Gutenberg-Richter’s Law: a Simple Deduction with Implications for Earthquake Sequence Analysis
We provide the derivation of Båth’s law from Gutenberg-Richter’s law with a simple deduction through Zipf distribution for a set of data exhibiting power law scaling. It turns out that D, the difference between t...
-
Article
Selective Catalytic Oxidation of Ammonia over Cr-Ce Mixed Oxide Catalysts in the Presence of Sulfur Dioxide
In this paper, the influence of SO2 on the performances of selective catalytic oxidation (SCO) of NH3 on Cr-Ce mixed oxide catalysts had been disclosed. Experimental results revealed that the existence of SO2 cou...
-
Article
Open AccessA novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression
Transforming growth factor beta (TGFβ) signaling plays a critical role in tumorigenesis and metastasis. However, little is known about the biological function of TGFbeta-induced lncRNA in cancer. In this study...
-
Article
Open AccessExploring the “gene–metabolite” network of ischemic stroke with blood stasis and toxin syndrome by integrated transcriptomics and metabolomics strategy
A research model combining a disease and syndrome can provide new ideas for the treatment of ischemic stroke. In the field of traditional Chinese medicine, blood stasis and toxin (BST) syndrome is considered a...
-
Article
Aconitum coreanum and processed products on its base prevent stroke via the PI3K/Akt and KEAP1/NRF2 in the in vivo study
Aconitum coreanum (A. coreanum), a traditional Chinese medicine, has been proved to treat ischemic stroke (IS). However, the mechanisms of A. coreanum’s anti-stroke is currently unknown. This study aimed to uncov...
-
Article
Open AccessAchieving Negatively Charged Pt Single Atoms on Amorphous Ni(OH)2 Nanosheets with Promoted Hydrogen Absorption in Hydrogen Evolution
Pt–Ni bonded Pt single-atom (SA) catalyst, rather than classic Pt–O bonded SA catalyst, was successfully constructed.
The el...
-
Article
A novel homozygous CLN6 Tyr142Cys variant in a nonconsanguineous family with Kufs disease
Neuronal ceroid lipofuscinoses are a genetically heterogeneous group of inherited lysosomal storage disorders. Kufs disease is the predominant form of neuronal ceroid lipofuscinosis in adults, but it’s rare an...
