23 Result(s)
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Article
Targets of monoclonal antibodies for immunological diseases
Immunological disorders such as allergy, autoimmune diseases, auto-inflammatory syndromes and immunological deficiency syndromes are difficult to treat with chemical drugs. Recently, many monoclonal antibodies...
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Article
IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by polyarthritis. Numerous agents with varying mechanisms are used in the treatment of RA, including non-steroidal anti-inflammatory dr...
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Clinical implication of SGLT2 inhibitors in type 2 diabetes
Treatment of type 2 diabetes mellitus (T2DM) continues to present challenges, with many patients failing to achieve glycemic targets. Despite the availability of many oral and injectable anti-diabetic agents, ...
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Article
Propofol Attenuates Pulmonary Injury Induced by Collapse and Reventilation of Lung in Rabbits
Propofol is an anesthetic drug with antioxidant and anti-inflammatory properties. We previously found that propofol attenuated lipopolysaccharide-induced acute lung injury in rabbits. This study was performed ...
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AMP-activated protein kinase: A potential target for ginsenosides?
Panax ginseng is a best-selling medicinal plant showing an antidiabetic activity via human, animal and in vitro studies. Among bioactive constituents found in ginseng, ginsenosides are known to be responsible for...
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In Vivo andIn Vitro anti-inflammatory activities of α-linolenic acid isolated from actinidia polygama fruits
The fruit ofActinidia polygama (AP) has long been used as a folk medicine in Korea for the treatment of pain, rheumatoid arthritis and inflammation. In the present study, bioassay-guided fractionation of AP led t...
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Vinegar- processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice
Ginseng has made a successful transition from the world of traditional tonic remedies to conventional medicine, and since the 1920s ginseng root has been documented to be effective in diabetes, hypertension, d...
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Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice
Non-alcoholic fatty liver disease (NAFLD) is common in obesity. However, weight reduction alone does not prevent the progression of NAFLD to end-stage disease associated with the development of cirrhosis and l...
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Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line
We recently reported that dimethylsphingosine (DMS), a metabolite of sphingolipids, increased intracellular pH and Ca2+ concentration in U937 human monocytes. In the present study, we found that dimethylphytosphi...
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Article
Salicornia herbacea prevents high fat diet-induced hyperglycemia and hyperlipidemia in ICR mice
Salicornia herbacea L. (Chenopodiaceae) has been used as a seasoned vegetable by living in coastal areas.S. herbacea (SH) has been demonstrated to stimulate cytokine production, nitric ox...
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Article
Antidiabetic stilbene and anthraquinone derivatives fromRheum undulatum
The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of ...
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Article
Antidiabetic coumarin and cyclitol compounds fromPeucedanum japonicum
The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix(Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclito...
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Article
Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in icr mice
Ginseng is a shade-loving perennial herb that is cultivated mainly in Korea, Japan, and China. The ginseng root has been used as a tonic remedy, and its antidiabetic activity has been demonstrated as early as ...
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Efficacy of Low-Dose Tamsulosin on Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia
To evaluate the efficacy and tolerability of tamsulosin 0.2mg once daily in Korean patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH), who were treated for up to...
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Article
Anti-Inflammation activity ofActinidia polygama
The fruit of Actinidia polygama (AP) has long been used as a folk medicine in Korea for treating pain, rheumatic arthritis and inflammation. The present investigation was carried out to determine thein vivo andin...
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Article
Long-term administration of sopungsungi-won (SP) prevents diabetic nephropathy in zucker diabetic fatty rats
We investigated the long term effects of Sopungsungi-won (SP), a Korean traditional formula used for senile constipation and diabetes mellitus, on the development of diabetic nephropathy (DN) in Zucker diabeti...
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Article
Sopungsungi-won (SP) prevents the onset of hyperglycemia and hyperlipidemia in zucker diabetic fatty rats
Sopungsungi-won (SP) is a known formula for senile constipation and diabetes mellitus, based on traditional Korean medicine. The preventive effect of SP on the development of overt diabetes in Zucker diabetic ...
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Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice
The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administr...
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Pharmacological characterization of (10bS)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline oxalate (YSL-3S) as a new α2-adrenoceptor antagonist
α2-Adrenoceptor antagonists, which can enhance synaptic norepinephrine levels by blocking feedback inhibition processes, are potentially useful in the treatment of disease states such as depression, memory impai....
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Article
Lipid peroxidation inhibitory activity of some constituents isolated from the stem bark ofEucalyptus globulus
Twelve compounds with lipid peroxidation inhibitory activity were isolated from the stem bark ofE. globulus. Their structures were assigned as a new aromatic monoterpene (1) and eleven known compounds, pinoresino...
