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Article
Open AccessGinsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor
We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials. We also demonstrated that dynorphin possesses an...
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Article
Ginsenoside Re Protects Trimethyltin-Induced Neurotoxicity via Activation of IL-6-Mediated Phosphoinositol 3-Kinase/Akt Signaling in Mice
Ginseng (Panax ginseng), an herbal medicine, has been used to prevent neurodegenerative disorders. Ginsenosides (e.g., Re, Rb1, or Rg1) were obtained from Korean mountain cultivated ginseng. The anticonvulsant ac...
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Article
Open AccessYY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2
Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a terpene trilactone-strengthened...
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Article
The effect of synthetic ceramide analogues on gastritis and esophagitis in rats
The effects of ceremide analogues on esophagitis and gastritis in rats were examined. Gastritis induced by indomethacin was significantly reduced after CY3325 and CY3723 treatment, whereas other analogues had ...
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Article
Ultrasonication processed Panax ginseng berry extract induces apoptosis through an intrinsic apoptosis pathway in HepG2 cells
Ginseng’s major active components, ginsenosides, have been known to show anti-cancer, neuroprotective, and anti-inflammatory activities. Ultrasonication processed Panax ginseng berry extract (UGB) contains variou...
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Article
Flavonoids from Pueraria mirifica roots and quantitative analysis using HPLC
The flavonoids, wighteone (1), naringenin (2), genistein (3), isoliquiritigenin (4), daidzein (5), daidzin (6), genistein-8-C-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside (7), ambocin (8), and genistin (9) were ...
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Article
Ginsenoside Re Rescues Methamphetamine-Induced Oxidative Damage, Mitochondrial Dysfunction, Microglial Activation, and Dopaminergic Degeneration by Inhibiting the Protein Kinase Cδ Gene
Ginsenoside Re, one of the main constituents of Panax ginseng, possesses novel antioxidant and anti-inflammatory properties. However, the pharmacological mechanism of ginsenoside Re in dopaminergic degeneration r...
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Article
A new miroestrol glycoside from the roots of Pueraria mirifica
A new compound, miroestrol-3-O-β-D-glucopyranoside, was isolated from the roots of Pueraria mirifica (white kwao krua). The structure of the compound was established on the basis of NMR, ESI-MS, and IR spectrosco...
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Article
Quantitative analysis of ginsenosides composition in flower buds of various ginseng plants
The content of ginsenosides in ginseng is known to differ based on the parts, including root, leaf, and flower buds. Ginseng flower buds cultivated in Korea and China contain the highest amount of Re of 3.455 ...
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Article
Change of Ginsenoside Composition of Various American Ginseng Roots
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Article
The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells
We investigated the signaling pathway on sphingosinephosphorylcholine (SPC) -induced contraction in cat esophageal smooth muscle cells. SPC induced in a dose-dependent manner contractile effect. We have previo...
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Article
Vinegar- processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice
Ginseng has made a successful transition from the world of traditional tonic remedies to conventional medicine, and since the 1920s ginseng root has been documented to be effective in diabetes, hypertension, d...
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Article
Salicornia herbacea prevents high fat diet-induced hyperglycemia and hyperlipidemia in ICR mice
Salicornia herbacea L. (Chenopodiaceae) has been used as a seasoned vegetable by living in coastal areas.S. herbacea (SH) has been demonstrated to stimulate cytokine production, nitric ox...
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Article
Extremely Low Frequency Magnetic Fields Modulate Bicuculline-lnduced-Convulsion in Rats
The effect of extremely low frequency (ELF, 60Hz) magnetic fields (MFs) on convulsions was investigated in rats. We determined the onset and duration of convulsions induced by bicuculline alone or by co-exposu...
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Article
Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in icr mice
Ginseng is a shade-loving perennial herb that is cultivated mainly in Korea, Japan, and China. The ginseng root has been used as a tonic remedy, and its antidiabetic activity has been demonstrated as early as ...
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Article
Sopungsungi-won (SP) prevents the onset of hyperglycemia and hyperlipidemia in zucker diabetic fatty rats
Sopungsungi-won (SP) is a known formula for senile constipation and diabetes mellitus, based on traditional Korean medicine. The preventive effect of SP on the development of overt diabetes in Zucker diabetic ...
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Article
A new stilbene diglycoside fromRheum undulatum
A new stilbene diglycoside, piceatannol-3, 4′-O-β-D-diglucopyranoside (I), together with desoxyrhaponticin (II), emodin-1-O-β-D-glucopyranoside (III), and physcion-8-O-b-D-glucopyranoside (IV), were isolated f...
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Article
Lupane-glycoside ofAcanthopanax trifoliatus formatristigmatis leaves
This report contains the first characterization of acanthodiolglycoside which belongs to pentacyclic lupane triterpene glycoside
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Article
Anti-platelet aggregation activity of stilbene derivatives fromRheum undulatum
In continued studies on cultivated Korean rhubarb rhizomes (Rheum undulatum), three known stilbenes (desoxyrhapontigenin, rhapontigenin, piceatannol) have been screened for activity on blood platelet aggregation....
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Article
Anthraquinone and stilbene derivatives from the cultivated Korean Rhubarb Rhizomes
The studies were carried out to evaluate the constituents in the rhizomes of the cultivated Korean Rhubarb (Polygonaceae). From the acetone fraction of methanol extract Compound 1 (1,8-dihydroxy-3-methyl anthr...
