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Article
Exploring pharmacokinetics and herb-drug interactions of an herbal extract mixture derived from Poria cocos and Morus alba L.
Poria cocos and Morus alba L., recognized as traditional Chinese medicines (TCMs), have gained attention for their diverse pharmacological effects. An herbal extract mixture (named as NB-02) combining these two b...
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Article
A New ent-kaurane Diterpene Glycoside from Seeds of Pharbitis nil
A new ent-kaurane diterpene glycoside, pharboside H (1), and three known compounds, benzyl β-D-glucopyranoside (2), 1-(4′-O-glucopyranosyl-4′-hydroxy-3′,5′-dimethoxyphenyl)-2{2′′,6′′-dimethoxy-4′′-[1-(E) propen-3...
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Article
Evaluation of drug--drug interaction potential between DA-9801 and metformin
DA-9801, the mixture extract of Dioscorea rhizoma and Dioscorea nipponica Makino, is a new herbal drug currently being evaluated in a phase II clinical study for the treatment of diabetic peripheral neuropathy. T...
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Article
Open AccessEvaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo
Drug transporters play important roles in the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. With a growing use of poly pharmacy, concurrent administration...
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Article
Evaluation of DA-9801, a new herbal drug for diabetic neuropathy, on metabolism-mediated interaction
DA-9801, the mixture extract of Dioscoreae rhizoma and Dioscorea nipponica Makino, is a new herbal drug currently being evaluated in a phase II clinical study for the treatment of diabetic peripheral neuropathy i...
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Article
Novel botanical drug for the treatment of diabetic neuropathy
Diabetic neuropathy has multiple aspects of pathophysiology including metabolic derangements and alterations of microvessel with hyperglycemia. Currently, there is no effective long-term treatment based on the...
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Article
Cytotoxic terpene hydroperoxides from the aerial parts ofAster spathulifolius
Three new sesquiterpene hydroperoxides, 1-[3-(2-hydroperoxy-3-methylbut-3-en)-4-hydroxyphenyl]ethanone (2), 7β-hydroperoxy-eudesma-11-en-4-ol (3), and 7α-hydroperoxymanool (4), together with three known compounds...
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Article
Cytotoxic terpenes and lignans from the roots ofAinsliaea acerifolia
The chromatographic separation of the MeOH extract of the roots ofAinsliaea acerifolia (Compositae) led to the isolation of six known terpenes and two known lignans. Their structures were identified by spectrosco...
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Article
Cytotoxic sesquiterpene lactones fromSaussurea calcicola
Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts ofSaussurea calcicola (Compositae). Their structures were determined spectroscopically to be cy...
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Article
Antidiabetic stilbene and anthraquinone derivatives fromRheum undulatum
The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of ...
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Article
Immunobioloical activity of a new benzyl benzoate from the aerial parts ofSolidago virga-aurea var.gigantea
The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts ofSolidago virga-aurea var.gigantea MIQ. (Compositae) led to the isolation of a new benzylbenzoate (1) tog...
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Article
Antidiabetic coumarin and cyclitol compounds fromPeucedanum japonicum
The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix(Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclito...
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Article
A new sesquiterpene lactone fromArtemisia rubripes nakai
The chromatographic separation of a methylene chloride extract ofArtemisia rubripes led to the isolation of a new sesquiterpene lactone (3), together with four known compounds, a coumarin (2) and three terpenes (
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Article
Pytochemical constituents of the aerial parts fromsolidago virga-aurea var. gigantea
The chromatographic separation of the MeOH extract of the aerial parts of Solidago virgaaurea var. gigantea MIQ. (Compositae) led to the isolation of six terpenoids and four phenolic compounds,frans-phytol (1),en...
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Article
A new sesquiterpene hydroperoxide from the aerial parts ofAster oharai
Phytochemical works on the aerial parts ofAster oharai (Compositae) led to the isolation of a new sesquiterpene hydroperoxide, 7α-hydroperoxy-3, 11-eudesmadiene (2) and seven known compounds, teucdiol B (1), α-sp...
