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Article
Targets of monoclonal antibodies for immunological diseases
Immunological disorders such as allergy, autoimmune diseases, auto-inflammatory syndromes and immunological deficiency syndromes are difficult to treat with chemical drugs. Recently, many monoclonal antibodies...
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Article
Open AccessMeta- and cross-species analyses of insulin resistance based on gene expression datasets in human white adipose tissues
Ample evidence indicates that insulin resistance (IR) is closely related to white adipose tissue (WAT), but the underlying mechanisms of IR pathogenesis are still unclear. Using 352 microarray datasets from se...
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Article
IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by polyarthritis. Numerous agents with varying mechanisms are used in the treatment of RA, including non-steroidal anti-inflammatory dr...
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Article
Clinical implication of SGLT2 inhibitors in type 2 diabetes
Treatment of type 2 diabetes mellitus (T2DM) continues to present challenges, with many patients failing to achieve glycemic targets. Despite the availability of many oral and injectable anti-diabetic agents, ...
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Article
Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer
Tumor hypoxia is considered the best validated target in clinical oncology because of its significant contribution to chemotherapy failure and drug resistance. As an approach to target hypoxia, we assessed the...
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Article
Protective effect of cinnamaldehyde on streptozotocin-induced damage in rat pancreatic β-cells
Cinnamaldehyde (CNA) is a primary constituent found in cinnamon (Cortex cinnamomi). Although antidiabetic and anti-inflammatory activities of cinnamon extract have been investigated in recent years, whether CNA i...
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Article
AMP-activated protein kinase: A potential target for ginsenosides?
Panax ginseng is a best-selling medicinal plant showing an antidiabetic activity via human, animal and in vitro studies. Among bioactive constituents found in ginseng, ginsenosides are known to be responsible for...
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Article
Ginsenoside 20(R)-Rg3 stimulates glucose uptake in C2C12 myotubes via CaMKK-AMPK pathways
Based upon preliminary study showing stimulation of glucose uptake by 20(R)-Rg3, a stereoisomer of 20(S)-Rg3 ginsenoside found in red ginseng, we investigated the action mechanism of 20(R)-Rg3 in differentiated C...
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Article
Korean red ginseng attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells
In this study, we examined Korean red ginseng (KRG) extract affects on the lipid metabolism in HepG2 cells. Increase in AMP-activated protein kinase (AMPK) phosphorylation was observed when the cells were trea...
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Article
Change of Ginsenoside Composition of Various American Ginseng Roots
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Article
In Vivo andIn Vitro anti-inflammatory activities of α-linolenic acid isolated from actinidia polygama fruits
The fruit ofActinidia polygama (AP) has long been used as a folk medicine in Korea for the treatment of pain, rheumatoid arthritis and inflammation. In the present study, bioassay-guided fractionation of AP led t...
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Article
Vinegar- processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice
Ginseng has made a successful transition from the world of traditional tonic remedies to conventional medicine, and since the 1920s ginseng root has been documented to be effective in diabetes, hypertension, d...
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Article
Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice
Non-alcoholic fatty liver disease (NAFLD) is common in obesity. However, weight reduction alone does not prevent the progression of NAFLD to end-stage disease associated with the development of cirrhosis and l...
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Article
Salicornia herbacea prevents high fat diet-induced hyperglycemia and hyperlipidemia in ICR mice
Salicornia herbacea L. (Chenopodiaceae) has been used as a seasoned vegetable by living in coastal areas.S. herbacea (SH) has been demonstrated to stimulate cytokine production, nitric ox...
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Article
Antidiabetic stilbene and anthraquinone derivatives fromRheum undulatum
The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of ...
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Article
Antidiabetic coumarin and cyclitol compounds fromPeucedanum japonicum
The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix(Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclito...
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Article
Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in icr mice
Ginseng is a shade-loving perennial herb that is cultivated mainly in Korea, Japan, and China. The ginseng root has been used as a tonic remedy, and its antidiabetic activity has been demonstrated as early as ...
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Article
Anti-Inflammation activity ofActinidia polygama
The fruit of Actinidia polygama (AP) has long been used as a folk medicine in Korea for treating pain, rheumatic arthritis and inflammation. The present investigation was carried out to determine thein vivo andin...
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Article
Long-term administration of sopungsungi-won (SP) prevents diabetic nephropathy in zucker diabetic fatty rats
We investigated the long term effects of Sopungsungi-won (SP), a Korean traditional formula used for senile constipation and diabetes mellitus, on the development of diabetic nephropathy (DN) in Zucker diabeti...
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Article
Sopungsungi-won (SP) prevents the onset of hyperglycemia and hyperlipidemia in zucker diabetic fatty rats
Sopungsungi-won (SP) is a known formula for senile constipation and diabetes mellitus, based on traditional Korean medicine. The preventive effect of SP on the development of overt diabetes in Zucker diabetic ...
