-
Article
Open AccessEpigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications
Advances in functional studies on epigenetic regulators have disclosed the vital roles played by diverse histone lysine demethylases (KDMs), ranging from normal development to tumorigenesis. Most of the KDMs a...
-
Article
Open AccessDrawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis
Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of cellular processes. Growing evidence shows that dynamic regulation of histone methylation is critical for almost all ...
-
Article
Open AccessHistone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc
Glioblastoma is the most lethal brain tumor and its pathogenesis remains incompletely understood. KDM4C is a histone H3K9 demethylase that contributes to epigenetic regulation of both oncogene and tumor suppre...
-
Article
Open AccessHPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53
E6 oncoprotein derived from high-risk human papillomavirus (HPV) drives the development of cervical cancer through p53 degradation. Because cervical cancer therapies to inactivate HPV or E6 protein are not ava...
-
Article
Measurements of the Specific Activities of 137Cs in Antarctica Environmental Samples by Using the Low-Level Radiation Analysis Method
Since the King Sejong Korean Antarctic Research Station began operation in 1988, studies of various fields have been then carried out in polar regions and significant achievements have been yielded. However, e...
-
Article
Open AccessAssessment of the Molecular Mechanism of Action of SB3, a Trastuzumab Biosimilar
SB3, a biosimilar of Herceptin® (trastuzumab, hereinafter referred to as reference product) is currently approved in the EU, Korea, Australia, the USA, and Brazil for the treatment of human epidermal growth facto...
-
Article
Open AccessAuthor Correction: An ADAMTS Sol narae is required for cell survival in Drosophila
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessADAMTS Sol narae cleaves extracellular Wingless to generate a novel active form that regulates cell proliferation in Drosophila
Wnt/ Wingless (Wg) is essential for embryonic development and adult homeostasis in all metazoans, but the mechanisms by which secreted Wnt/Wg is processed remain largely unknown. A Drosophila Sol narae (Sona) is ...
-
Article
Open AccessIntegrative genomic and transcriptomic analysis of genetic markers in Dupuytren’s disease
Dupuytren’s disease (DD) is a fibroproliferative disorder characterized by thickening and contracting palmar fascia. The exact pathogenesis of DD remains unknown.
-
Article
Open AccessAn ADAMTS Sol narae is required for cell survival in Drosophila
Cell survival is essential for all living organisms to cope against multiple environmental insults. Intercellular signaling between dying and surviving cells plays an important role to ensure compensatory prol...
-
Article
Open AccessMeta- and cross-species analyses of insulin resistance based on gene expression datasets in human white adipose tissues
Ample evidence indicates that insulin resistance (IR) is closely related to white adipose tissue (WAT), but the underlying mechanisms of IR pathogenesis are still unclear. Using 352 microarray datasets from se...
-
Article
Open AccessSol narae (Sona) is a Drosophila ADAMTS involved in Wg signaling
ADAMTS (a disintegrin and metalloproteases with thrombospondin motif) family consists of secreted proteases, and is shown to cleave extracellular matrix proteins. Their malfunctions result in cancers and disor...
-
Article
IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by polyarthritis. Numerous agents with varying mechanisms are used in the treatment of RA, including non-steroidal anti-inflammatory dr...
-
Article
Clinical characteristics of spontaneous cholesteatoma of the external auditory canal in children comparing with cholesteatoma in adults
The purpose of this study was to investigate the characteristics of external auditory canal cholesteatoma (EACC) in children through evaluation of the clinical and radiologic features as well as treatment outc...
-
Article
Clinical implication of SGLT2 inhibitors in type 2 diabetes
Treatment of type 2 diabetes mellitus (T2DM) continues to present challenges, with many patients failing to achieve glycemic targets. Despite the availability of many oral and injectable anti-diabetic agents, ...
-
Chapter
K-Acetylation and Its Enzymes: Overview and New Developments
Lysine (K) acetylation refers to transfer of the acetyl moiety from acetyl-CoA to the ε-amino group of a lysine residue. This is posttranslational and reversible, with its level dynamically maintained by lysin...
-
Article
Diffraction behaviors of new photopolymers containing the dendritic molecule
Photopolymers are attractive materials for holographic 3-D data storage because of their high photosensitivity and large refractive index modulation. We synthesized the six-armed dendrimer for fabricating the ...
-
Article
Photochromic behavior and its stability of a new bifunctional dye composed of spirobenzopyran and a cinnamoyl moiety
A novel bifunctional dye composed of spirobenzopyran and a cinnamoyl moiety was prepared and its photochromic behavior under the illumination of monochromatic UV light was investigated. This colorless bifuncti...
