Abstract
Ginseng has made a successful transition from the world of traditional tonic remedies to conventional medicine, and since the 1920s ginseng root has been documented to be effective in diabetes, hypertension, dyslipidemia and obesity. Based on this wide spectrum of activity we wondered whether ginseng root extract might also be effective in metabolic syndrome (MetSyn). In a series of investigations to develop a potential anti-MetSyn agent, we prepared a vinegar-processed form of ginseng radix (ginsam, GS) and compared its anti-MetSyn effects to those of non-processed ginseng radix (GR) in an ICR mouse model of MetSyn induced by a high fat diet. GR- and GS-treated mice (500 mg/kg/day for 8 weeks) had an 81% and 90% decrease in insulin resistance respectively, compared to the high fat diet (HFD) control. White adipocyte size was dramatically reduced by 67% and 80% in GR- and GS-treated groups respectively, compared to the HFD fed control. This result was reflected by a marked inhibition of weight gain in GS-treated mice (GR vs. GS, 53% vs. 86%). Analysis of ginsenoside composition indicated that prosapogenin Rg3 might be responsible for the anti-MetSyn activity of GS. In conclusion, Vinegar-processed ginseng radix (GS) was found to have a significantly greater anti-MetSyn effect than ginseng radix, and we suggest that ginsam should be subjected to clinical trials in the future, and that the role of prosapogenin Rg3 in the anti-MetSyn effect of ginsam should be confirmed.
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References
Adult Treatment Panel III. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults.Final report. Circulation, 106, 3143–3421 (2002).
Athyros, V. G., Ganotakis, E. S., Elisaf, M., and Mikhailidis, D. P., The prevalence of the metabolic syndrome using the National Education Program and International Diabetes Federation definitions.Curr. Med. Res. Opin., 21, 1157–1159 (2005).
Attele, A. S., Zhou, Y. P., **e, J. T., Wu, J. A., Zhang, L., Dey, L., Pugh, W., Rue, P. A., Polonsky, K. S., and Yuan, C. S., Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.Diabetes, 51, 1851–1858 (2002).
Chen, M., Zhao, L., and Jia, W., Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model.J. Proteome Res., 4, 2391–2396 (2005).
Chevallier, A., Encyclopedia of herbal medicine. New York: DK Publishing (2000).
Chung, S. H., Choi, C. G., and Park, S. H., Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice.Arch. Pharm. Res., 24, 214–218 (2001).
Dyson, M. C., Alloosh, M., Vuchetich, J. P., Mokelke, E. A., and Sturek, M., Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet.Comp Med., 56, 35–45 (2006).
Gazi, I., Liberopoulos, E., Mikhailidis, D. P., and Elisaf, M., Metabolic syndrome: clinical features leading to therapeutic strategies.Vas Dis. Prey., 1, 243–253 (2004).
Grundy, S., Brewer, B., Cleeman, J., Smith, S., and Lenfant, C., Definition of metabolic syndrome: report of the National Heart, Lung and Blood Institute/American Heart Association Conference on Scientific definition.Circulation, 109, 433–438 (2004).
Hwang, I. S., Ho, H., Hoffman, B. B., and Reaven, G. M., Fructose-induced insulin resistance and hypertension in rats.Hypertension, 10, 512–516 (1987).
Jeon, B. H., Kim, C. S., Kim, H. S., Park, J. B., Nam, K. Y., and Chang, S. J., Effect of Korean red ginseng on blood pressure and nitric oxide production.Acta. Pharmacol. Sin., 21, 1095–1100 (2000).
Kim, S. H. and Park, K. S., Effects of Panax ginseng extract on lipid metabolism in humans.Pharmacol. Res., 48, 511–513 (2003).
McFarlane, S. I., Banerji, M., and Sowers, J. R., Insulin resistance and cardiovascular disease.J. Clin. Endocrinol. Metab., 86, 716–718 (2001).
Oron-Herman, M., Rosenthal, T., Mirelman, D., Miron, T., Rabinkov, A., Wilchek, M., and Sela, B. A., The effects of Sallylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome.Atheroscelosis, 183, 238–243 (2005).
Reaeven, G. M., Role of insulin resistance in human disease.Diabetes, 37, 1595–1607 (1998).
Reaeven, G. M., The metabolic syndrome: requiescat in pace.Clin. Chem., 51, 931–938 (2005).
Sheu, W. H., Jeng, C. Y., Young, M. S., Le, W. J., and Chen, Y. T., Coronary artery disease risk predicted by insulin resistance, plasma lipids, and hypertension in people without diabetes,Am. J. Med. Sci., 319, 84–88 (2000).
Sievenpiper, J. L., Arnason, J. T., Leiter, L. A., and Vuksan, V., Variable effect s of American ginseng: a batch of American ginseng with a depressed ginsenoside profile does not affect postprandial glycemia.Eur. J. Clin. Nutr., 57, 243–248 (2003).
Sievenpiper, J. L., Arnason, J. T., Lawrence, A., Leiter, L. A., and Vuksan, V., Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides.J. Am. Coll. Nutr., 23, 248–258 (2004).
Sotaniemi, E. A., Haapakoski, E., and Rautio, A., Ginseng therapy in non-insulin-dependent diabetic patients.Diabetes Care, 18, 1373–1375. (1995).
Sung, J., Han, K. H., Zo, J. H., Park, H. J., Kim, C.H. and Oh, B. H., Effects of red ginseng upon vascular endothelial function in patients with essential hypertension.Am. J. Chin. Med., 28, 205–216 (2000).
The IDF consensus worldwide definition of the metabolic syndrome, http://www.idf.org/webdata/doc/IDF-Metasyndrome_ definition.pdf (2005).
Vuksan, V., Sievenpiper, J. L., Xu, Z., Wong, E. Y., Jenkins, A. L., and Beljan-Zdrakovic, U., Konjac-mannan and American ginseng: emerging alternative therapies for type 2 diabetes mellitus.J. Am. Coll. Nutr., 20, 370S-380S (2001).
Wang, B. X., Advances in study of pharmacology of ginseng.Acta. Pharmacol. Sin., 12, 477–486 (1965).
Yun, S. N., Moon, S. J., Ko, S. K., Im, B. O., and Chung, S. H., Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in ICR mice.Arch. Pharm. Res., 27, 790–796 (2005).
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Yun, S.N., Ko, S.K., Lee, K.H. et al. Vinegar- processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice. Arch Pharm Res 30, 587–595 (2007). https://doi.org/10.1007/BF02977653
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DOI: https://doi.org/10.1007/BF02977653