-
Article
Open AccessRelationship between psycho-physiological indicators and task performance under various indoor space designs for telecommuting environment by introducing mixed-reality
The increase in telecommuting during COVID-19 and advances in digital technology have necessitated the establishment of guidelines for maximizing productivity through indoor space design for telecommuters. Add...
-
Article
New secondary metabolites produced by Paraphoma radicina FB55 as potential antifungal agents
Microorganisms in specific environments are rich sources of bioactive natural products as they produce compounds that can aid their survival in harsh environments. In an effort to investigate antifungal compou...
-
Article
Project Coordinators’ Perceptions according to the Organization Structure to Reduce Communication Risks in Multinational Project
Increasing risks about deficient communication and difficulties in communication management in multinational projects lead to the deployment of project coordinators (PCs). The role of coordinators and their re...
-
Article
Open AccessThe Japanese version of the Material Values Scale: construct assessment and relationship with age, personality, and subjective well-being
Materialism indicates the extent to which an individual’s life is focused on consumerism, or the acquisition of money and possessions. The Material Values Scale (MVS), comprising the factors “success,” “centralit...
-
Article
The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis
Systemic candidiasis, which is mainly caused by Candida albicans, is a serious acute fungal infection in the clinical setting. In a previous study, we reported that compound 22h (designated as AB-22 in this study...
-
Article
Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells
In the present work, a new series of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine possessing terminal ethyl or propyl sulfonamides was designed and synthesized. The cytotoxic effect of the final compou...
-
Article
Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier
The neurovascular unit, which consists of vascular cells surrounded by astrocytic end-feet and neurons, controls cerebral blood flow and the permeability of the blood–brain barrier (BBB) to maintain homeostasi...
-
Article
A Signature-Tagged Mutagenesis (STM)-based murine-infectivity assay for Cryptococcus neoformans
Signature-tagged mutagenesis (STM) is a high-throughput genetic technique that can be used to investigate the function of genes by constructing a large number of mutant strains with unique DNA identification t...
-
Article
Open AccessGenome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans
Phosphatases, together with kinases and transcription factors, are key components in cellular signalling networks. Here, we present a systematic functional analysis of the phosphatases in Cryptococcus neoformans,...
-
Article
Effect of the Plasma Jet Ignition and Flame Kernel Under The Combustion Process in a Constant Volume Combustion Chamber
This work is to study the plasma application using a capacitive discharge ignition capable of using the plasma jet which belongs to the non-thermal plasma physic. A plasma-jet spark plug was designed to combin...
-
Article
Open AccessFungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans
Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) crossing and brain infection in mice...
-
Article
Understanding of the Spark Effect of Electron Collision by a Capacitive Discharge Ignition in a Constant Volume Combustion Chamber
This work is to investigate the physical effect of plasma discharge in atmospheric air using a capacitive discharge ignition (CDI) system. Also, to specifically investigate the kernel effects of CDI system, th...
-
Article
Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects
Phytochemical investigation on the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new non-glycosidic iridoids, patriscabrins F–J (1–5), along with a k...
-
Article
Saikosaponin B2 Suppresses Inflammatory Responses Through IKK/IκBα/NF-κB Signaling Inactivation in LPS-Induced RAW 264.7 Macrophages
Bupleurum falcatum (Umbelliferae) have been widely used to treat inflammatory diseases as traditional medicines in East Asian region. Although saikosaponins are main bioactive molecules of B. falcatum, there is l...
-
Article
Open AccessEvolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex
The unfolded protein response (UPR) pathway, consisting of the evolutionarily conserved Ire1 kinase/endonuclease and the bZIP transcription factor Hxl1, is critical for the pathogenicity of Cryptococcus neoforman...
-
Article
Open AccessAsymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle
To unravel metabolic determinats of insulin resistance, we performed a targeted metabolomics analysis in Korean Children-Adolescent Cohort Study (KoCAS, n = 430). Sixty-seven metabolites were associated with i...
-
Article
Biotransformation of fatty acid-rich tree oil hydrolysates to hydroxy fatty acid-rich hydrolysates by hydroxylases and their feasibility as biosurfactants
The fatty acid compositions of 10 types of tree oils were analyzed and Camellia japonica (CJ), Tetradium daniellii (TD), and Hovenia dulcis (HD) tree oils were selected to be oleic acid (OA)-, linoleic acid (LA)-...
-
Article
Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages
The inhibition of nitric oxide and prostaglandin E2 productions is a very interesting research topic in the field of anti-inflammatory drug development. In the current study, a new series of 1,3,4-triarylpyrazole...
-
Article
Open AccessRoxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation
Roxatidine is an active metabolite of roxatidine acetate hydrochloride which is a histamine H2-receptor antagonist that is used to treat gastric and duodenal ulcers. In this study, we investigated the anti-allerg...
-
Article
Socio-economic impact of renewable energy-based power system in mountainous villages of Nepal
Off-grid power system is well acknowledged as a viable alternative to grid extension in rural areas of develo** countries. A significant portion of such projects has been installed in many develo** countri...
