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Article
Open AccessAntisecretory factor in breastmilk is associated with reduced incidence of sepsis in preterm infants
Antisecretory Factor (AF) is a protein present in breastmilk that regulates inflammatory processes. We aimed to investigate the level of AF in mothers’ own milk (MOM) in relation to sepsis and other neonatal m...
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Article
Climate impacts on global agriculture emerge earlier in new generation of climate and crop models
Potential climate-related impacts on future crop yield are a major societal concern. Previous projections of the Agricultural Model Intercomparison and Improvement Project’s Global Gridded Crop Model Intercomp...
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Article
Open AccessElevated intracranial pressure after head trauma can be suppressed by antisecretory factor—a pilot study
Control of intracranial pressure (ICP) is a key element in neurointensive care for directing treatment decisions in patients with severe traumatic brain injury (TBI). The anti-inflammatory protein antisecretor...
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Article
Krebsfrüherkennung und Risiko der Überdiagnose
In den letzten Jahren wurde der Blick darauf geschärft, dass Früherkennung nicht nur Nutzen haben, sondern auch relevanten gesundheitlichen Schaden anrichten kann. Der Schaden ist aber meist deutlich schwierig...
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Article
Open AccessIncreased level of compleasomes in cerebrospinal fluid of patients with herpes simplex encephalitis
Herpes simplex encephalitis (HSE) is a common cause of viral encephalitis (HSV-1) characterised by pronounced inflammation and elevated intracranial pressure. We have shown in a rat model that HSV-1 infection ...
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Chapter
Der Optimierend-Planende
Sennett (1998) würde den Optimierend-Planenden vermutlich – metaphorisch gesprochen – als einen Hybriden zwischen dem sogenannten Drifter und dem Surfer bezeichnen. Der Optimierend-Planende segelt zufrieden im vo...
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Article
Research strategy of the German Agricultural Research Alliance (DAFA) for the development of the organic farming and food sector in Germany
The Federal Government of Germany regards organic farming as particularly resource-efficient and environmentally sustainable economic activity. It therefore supports the expansion of organic farming up to 20% ...
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Article
Open AccessReaction of complement factors and proteasomes in experimental encephalitis
Herpes simplex virus type 1 (HSV-1) encephalitis causes a deleterious inflammation and elevated intracranial pressure. As a step towards examining the origin of the inflammation, we here report the response of...
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Article
Open AccessFood-induced changes of lipids in rat neuronal tissue visualized by ToF-SIMS imaging
Time of flight secondary ion mass spectrometry (ToF-SIMS) was used to image the lipid localization in brain tissue sections from rats fed specially processed cereals (SPC). An IonTof 5 instrument equipped with...
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Article
Inconsistent conclusions on QoL outcomes from the same clinical trial
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Article
Open AccessNon-allergenic factors from pollen modulate T helper cell instructing notch ligands on dendritic cells
Pollen allergens are delivered to epithelial surfaces of the upper respiratory tract in conjunction with multiple endogenous adjuvants. We previously demonstrated pollen-mediated modulation of cytokine and che...
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Article
Regional climate model sensitivities to parametrizations of convection and non-precipitating subgrid-scale clouds over South America
This study provides a first thorough evaluation of the COnsortium for Small scale MOdeling weather prediction model in CLimate Mode (COSMO-CLM) over South America. Simulations are driven by ERA-Interim reanaly...
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Article
Novel rat models to study primary genital herpes simplex virus-2 infection
In this study we describe that six rat models (SD, WIST, LEW, BN, F344 and DA) are susceptible to intravaginal herpes simplex virus-2 (HSV-2) infection after pre-treatment with progesterone. At a virus dose of...
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Article
The anterior commissure is a pathway for contralateral spread of herpes simplex virus type 1 after olfactory tract infection
Herpes simplex encephalitis (HSE), targeting the limbic system, is the most common cause of viral encephalitis in the Western world. Two pathways for viral entry to the central nervous system (CNS) in HSE have...
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Article
Nutzenbewertung medizinischer Leistungen im deutschen Gesundheitswesen – rechtlicher Rahmen, historische und internationale Perspektive
Nutzen in einem medizinischen Kontext beschreibt die (positiven) kausalen patientenrelevanten Folgen einer medizinischen Intervention, sei es Diagnostik oder Behandlung. Nutzenbewertungen bilden die Grundlage ...
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Article
Open AccessComplex networks for climate model evaluation with application to statistical versus dynamical modeling of South American climate
In this study we introduce two new node-weighted difference measures on complex networks as a tool for climate model evaluation. The approach facilitates the quantification of a model’s ability to reproduce th...
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Article
Open AccessUptake of the antisecretory factor peptide AF-16 in rat blood and cerebrospinal fluid and effects on elevated intracranial pressure
AF-16 is a 16-amino-acid-long peptide derived from the amino-terminal part of the endogenous protein, antisecretory factor (AF). AF-16 in vivo has been shown to regulate dysfunctions in the water and ion trans...
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Chapter and Conference Paper
Real-Life Deployment of Bluetooth Scatternets for Wireless Sensor Networks
Bluetooth scatternets are constructed from overlap** piconets, allowing any number of nodes to be connected into a multi-hop wireless network. Although the topic has been researched for 15 years, no deployme...
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Chapter and Conference Paper
Measurement of Risk for Wind Energy Projects: A Critical Analysis of Full Load Hours
In scientific literature, profitability analyses of on- and offshore wind energy projects and assessments of general conditions for such projects usually make use of the full load hours (FLH) key figure to det...
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Chapter
The Peptide AF-16 and the AF Protein Counteract Intracranial Hypertension
Intracranial hypertension develops after, for example, trauma, stroke and brain inflammation, and contributes to increased morbidity, mortality, and persistent neuropsychiatric sequelae. Nonsurgical therapy of...
