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Article
Utilization of waste vanadium-bearing resources in the preparation of rare-earth vanadate catalysts for semi-hydrogenation of α,β-unsaturated aldehydes
Recycling industrial solid waste not only saves resources but also eliminates environmental concerns of toxic threats. Herein, we proposed a new strategy for the utilization of petrochemical-derived carbon bla...
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Article
Open AccessAuthor Correction: Aptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessProteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells
Drug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic endonuclease 1 (APE1) expression. Herein, we investigated the role of APE1 and...
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Article
Open AccessCarbon nanoparticles with oligonucleotide probes for a label-free sensitive antibiotic residues detection based on competitive analysis
Carbon nanoparticles (CNPs) have been combined with aptamer, providing a broad application in small molecule. CNPs can be quenched by small molecules and are usually applied as luminescent probes because of th...
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Article
A betaine aldehyde dehydrogenase gene from Ammopiptanthus nanus enhances tolerance of Arabidopsis to high salt and drought stresses
Glycine betaine functions as an osmotic protectant in response of plant to abiotic stresses. In higher plants, the betaine aldehyde dehydrogenase (BADH) catalyzes the key step of glycine betaine biosynthesis. ...
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Article
Open AccessAptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells
The development of chemoresistance and inability in elimination of cancer stem cells are among the key limitations of cancer chemotherapy. Novel molecular therapeutic strategies able to overcome such limitatio...
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Article
Cloning and characterization of vacuolar H+-pyrophosphatase gene (AnVP1) from Ammopiptanthus nanus and its heterologous expression enhances osmotic tolerance in yeast and Arabidopsis thaliana
Vacuolar H+-pyrophosphatase (H+-PPase) is one of the proton pumps involved in the response of plants to osmotic stress. In the present study, the vacuolar H+-PPase gene (AnVP1) was cloned from an epibiotic super-...
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Article
Phospholipase D family and its expression in response to abiotic stress in maize
Phospholipase D hydrolyzes phospholipids into phophatidic acid and choline, and plays important roles in growth, development, and stress response. Genome-wide identification for the PLD gene family has been ma...
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Article
Open AccessBiochemical mechanism underlying hypertriglyceridemia and hepatic steatosis/hepatomegaly induced by acute schisandrin B treatment in mice
It has been demonstrated that acute oral administration of schisandrin B (Sch B), an active dibenzocyclooctadiene isolated from Schisandrae Fructus (a commonly used traditional Chinese herb), increased serum a...
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Article
Sorafenib combined with transarterial chemoembolization in patients with hepatocellular carcinoma: a meta-analysis and systematic review
Combination therapy of sorafenib and transarterial chemoembolization (TACE) has shown benefits in treating advanced hepatocellular carcinoma (HCC). This study evaluated the efficacy and safety of TACE + sorafe...
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Article
Overexpression of a phospholipase Dα gene from Ammopiptanthus nanus enhances salt tolerance of phospholipase Dα1-deficient Arabidopsis mutant
A phospholipase Dα gene ( AnPLDα ) was cloned from xerophytic desert plant Ammopiptanthus nanus and its overexpression en...
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Article
Open AccessRenal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin–angiotensin system
(Pro)renin receptor (PRR) is a new component of the renin–angiotensin system and regulates renin activity in vitro. Within the kidney, PRR is highly expressed in the renal medulla where its expression is induc...
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Article
Cloning and functional validation of molybdenum cofactor sulfurase gene from Ammopiptanthus nanus
The molybdenum cofactor sulfurase gene ( AnMCSU ) was cloned from xerophytic desert plant Ammopiptanthus nanus ...
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Article
Clinical Association Between Pharmacogenomics and Adverse Drug Reactions
Adverse drug reactions (ADRs) are a major public health concern and cause significant patient morbidity and mortality. Pharmacogenomics is the study of how genetic polymorphisms affect an individual’s response...
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Article
Expression Profile of Maize MicroRNAs Corresponding to Their Target Genes Under Drought Stress
Microarray assay of four inbred lines was used to identify 303 microRNAs differentially expressed under drought stress. The microRNAs were used for bioinformatics prediction of their target genes. The majority...
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Article
Open AccessDietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet
Recently, it has been found that Fructus Schisandra Chinensis (FSC), a Chinese herbal medicine, and its related compounds have a profound impact on lipid metabolism process. FSC can be divided into two parts, i.e...
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Article
Cyclodextrin-based targeting strategies for tumor treatment
The efficacy and applicability of anticancer drugs are greatly restricted by severe systemic toxicities and drug resistance. Targeting drug delivery strategies have been developed to prevent the shortcomings o...
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Article
RNA interference-mediated resistance to maize dwarf mosaic virus
Maize dwarf mosaic virus (MDMV) is a widespread pathogen that causes serious yield loss to maize crops. A hairpin RNA expression vector was constructed herein to overcome the low efficiency of cultural protect...
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Article
Efficacy of a Therapeutic Vaccine Using Mutated β-amyloid Sensitized Dendritic Cells in Alzheimer’s Mice
Despite FDA suspension of Elan’s AN-1792 amyloid beta (Aβ) vaccine in phase IIb clinical trials, the implications of this study are the guiding principles for contemporary anti-Aβ immunotherapy against Alzheim...
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Pharmacokinetics of Anticancer Materia Medica in Humans
A number of herbal medicines are increasingly used in cancer patients, despite the fact that the clinical evidence that support the use of these herbal medicines to fight cancer is weak or lacking. Pharmacokin...
