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  1. Article

    Open Access

    Automated radiosynthesis of pharmaceutical grade [68Ga]Ga-NODAGA-Lys40-Exendin-4 and demonstration of its efficacy for use in patients

    The radiosynthesis of pharmaceutical grade [68Ga]Ga-NODAGA-Lys40-Exendin-4 was accomplished in a fixed tubing-based module, EZ Modular-Lab Standard. Purification of the product via hydrophilic-lipophilic balance ...

    Sreeja Raj Menon, Arpit Mitra… in Journal of Radioanalytical and Nuclear Che… (2024)

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  2. No Access

    Article

    On the production of pharmaceutical grade indium-111-chloride in the medical cyclotron from natural cadmium target and its use in formulation of diagnostic patient dose of 111In-pentetreotide for imaging somatostatin receptor overexpression

    A prototype, semi-automated, indigenous solid-target assembly has been developed to produce clinical grade 111InCl3 from natCd targets. Fluka Monte Carlo code was used to estimate the optimum proton energy range ...

    Kanchan Kushwaha, Arpit Mitra… in Journal of Radioanalytical and Nuclear Che… (2021)

  3. No Access

    Article

    Clinical efficacy of Sep-Pak® assisted one pot automated synthesis of pharmaceutical grade [18F]FLT using 5′-O-(benzoyl)-2,3′-anhydrothymidine precursor

    An automated production of pharmaceutical grade 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) with solid phase extraction (SPE) purification using 5′-O-(Benzoyl)-2,3′anhydrothymidine precursor (Benzoyl-Anhydro) pos...

    Arpit Mitra, Avik Chakraborty… in Journal of Radioanalytical and Nuclear Che… (2021)

  4. No Access

    Article

    Novel radioassay for anti-thyroperoxidase autoantibodies using protein A coupled magnetizable cellulose particles as an immunoadsorbent

    Autoantibodies against thyroid peroxidase (TPO); described initially as thyroid microsomal antigen, are found in most of the patients with autoimmune thyroid disorders. The present study comprised of developme...

    Chandrakala Gholve, Sharmila Banerjee… in Journal of Radioanalytical and Nuclear Che… (2020)

  5. No Access

    Article

    Purification of 99Mo and 99mTc from radioactive traces of Nb, Zr, and Y impurities: method applicable in the purification of the spent 100/99Mo–99mTc generator

    The aim of this work was to develop a method for purification of the spent 100/99Mo–99mTc generator free from non-isotopic impurities like Nb, Y, Zr and recovery of 99mTc using a Sephadex column and MEK solvent e...

    Sankha Chattopadhyay, Sujata Saha Das… in Journal of Radioanalytical and Nuclear Che… (2019)

  6. No Access

    Article

    Microarray immunoassay for thyrotropin on track-etched membranes using radiotracers

    We report a microarray immunoassay for thyrotropin in serum using an anti-thyrotropin monoclonal ‘antibody-chip’ fabricated on polycarbonate track-etched membranes as a solid-support. The thyrotropin microarra...

    Bharti Jain, Savita Kulkarni… in Journal of Radioanalytical and Nuclear Che… (2019)

  7. No Access

    Article

    Preparation and preliminary evaluation of a tris-metronidazole-99mTc(CO)3 complex for targeting tumor hypoxia

    Conventional 99mTc-radiopharmaceuticals for the detection of tumor hypoxia generally possess a single nitroimidazole moiety. Herein, we report the synthesis and evaluation of a 99mTc-complex with three-nitroimida...

    Madhava B. Mallia, Anupam Mathur… in Journal of Radioanalytical and Nuclear Che… (2018)

  8. No Access

    Article

    Synthesis of O-(1′-[18F]fluoropropan-2′-yl)-l-tyrosine (1-[18F]FPT) via Ni(II) complex of (S) tyrosine schiff’s base precursor

    O-(1′-[18F]fluoropropan-2′-yl)-l-tyrosine (1-[18F]FPT) was synthesized using the Ni(II)-(S)-[N-2-(N′-benzylprolyl)amino]benzophenone-S-tyrosine based precursor. The precursor was synthesized through a two-step pr...

    N. Lakshminarayanan, Sharmila Banerjee… in Journal of Radioanalytical and Nuclear Che… (2017)

  9. No Access

    Article

    Preparation and preliminary bioevaluation of 68Ga-oxine in lipiodol as a potential liver imaging agent

    Lipiodol functions as an embolizing agent for trans-arterial embolization and is used to deliver localized doses of chemotherapeutic drugs as well as ionizing radiation to cancerous tissue of the liver. Theref...

    Subhajit Ghosh, Tapas Das, Haladhar D. Sarma… in Journal of Radioanalytical and Nuclear Che… (2017)

  10. No Access

    Article

    Preparation and bioevaluation of [99mTcN]2+-labeled tetrameric complex of E-c(RGDfK)2 as a radiotracer for imaging αvβ3 integrins in tumors

    The objective of the present work is to radiolabel a dimeric RGD peptide namely, E-c(RGDfK)2 using [99mTcN]2+ core in order to obtain a 99mTc-labeled tetrameric RGD species, which is expected to have an enhanced ...

    Mohini Guleria, Subhajit Ghosh, Tapas Das… in Journal of Radioanalytical and Nuclear Che… (2016)

  11. Article

    Open Access

    18th European Symposium on Radiopharmacy and Radiopharmaceuticals

    OP03 Selective extraction of medically-related radionuclides from proton-irradiated thorium targets

    V. Radchenko, J. W. Engle, C. Roy, J. Griswold… in EJNMMI Radiopharmacy and Chemistry (2016)

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  12. No Access

    Article

    Synthesis and evaluation of a novel 99mTcN(PNP)-complex with metronidazole isocyanide ligand as a marker for tumor hypoxia

    The [99mTcN(PNP)]2+ core offers a unique route for the preparation of asymmetric 99mTc-complexes. Though bidentate chelators such as dithiocarbamates are most commonly used ligands in this approach, present study...

    Kusum Vats, Madhava B. Mallia, Anupam Mathur… in Journal of Radioanalytical and Nuclear Che… (2016)

  13. No Access

    Article

    Synthesis and bioevaluation of a 177Lu-labeled unsymmetrical cationic porphyrin derivative as a tumor targeting agent

    A cationic porphyrin derivative namely, 5-carboxymethyleneoxyphenyl-10,15,20-tri(p-N-methylpyridyl)porphyrin was synthesized and conjugated with a bi-functional chelating agent namely, p-NH2-benzyl-DOTA (p-aminob...

    Mohini Guleria, Tapas Das… in Journal of Radioanalytical and Nuclear Che… (2016)

  14. No Access

    Article

    Neutral 99mTc(CO)3 complexes of “clicked” nitroimidazoles for the detection of tumor hypoxia

    In the present work, three neutral 99mTc(CO)3 complexes of nitroimidazole were synthesized and their potential to detect tumor hypoxia is evaluated in vivo. Triazole derivatives of 2-, 4- and 5-nitroimidazole wer...

    Mohini Bhadwal, Madhava B. Mallia… in Journal of Radioanalytical and Nuclear Che… (2016)

  15. No Access

    Article

    Formulation and radiochemical evaluation of a freeze-dried mixed peptide kit for the preparation of 68Ga-labeled peptides for PET imaging of somatostatin receptor positive neuroendocrine cancers

    68Ga-labeled DOTA-coupled somatostatin analogue peptides are regularly being used for the PET imaging of patients suspected to be suffering from various types of neuroendocrine cancers over-expre...

    Tapas Das, Mohini Bhadwal, H. D. Sarma… in Journal of Radioanalytical and Nuclear Che… (2014)

  16. No Access

    Article

    Synthesis and evaluation of a phenylbenzothiazole-based 99mTc(CO)3-radiotracer for possible application in imaging of β-amyloid plaques in Alzheimer’s disease

    The 2-phenyl benzothiazole pharmacophore is known to have high affinity for amyloid beta (Aβ) and is therefore derivatized, to [N-(4′-benzothiazol-pyridin-2-yl-methyl-amino)-acetic acid (BTPAA)] for radiolabeling...

    Drishty Satpati, Aruna Korde, H. D. Sarma… in Journal of Radioanalytical and Nuclear Che… (2014)

  17. No Access

    Article

    Preparation of DOTA-TATE and DOTA-NOC freeze-dried kits for formulation of patient doses of 177Lu-labeled agents and their comparison for peptide receptor radionuclide therapy application

    The objective of the present work is to prepare freeze-dried DOTA-TATE and DOTA-NOC kits for the easy and convenient preparation of patient doses of 177Lu-DOTA-TATE and 177Lu-DOTA-NOC, respectively at the hospita...

    Tapas Das, Mohini Bhadwal, Sharmila Banerjee… in Journal of Radioanalytical and Nuclear Che… (2014)

  18. No Access

    Article

    Radiosynthesis and in vitro evaluation of 99mTc(CO)3-labeled folic acid derivative

    The over-expression of folate receptors in variety of neoplastic tissues makes radiolabeled folate conjugates potential agents for imaging and therapy of such cancers. With the aim of preparing an imaging agen...

    Drishty Satpati, Archana Mukherjee… in Journal of Radioanalytical and Nuclear Che… (2011)