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On the production of pharmaceutical grade indium-111-chloride in the medical cyclotron from natural cadmium target and its use in formulation of diagnostic patient dose of 111In-pentetreotide for imaging somatostatin receptor overexpression

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Abstract

A prototype, semi-automated, indigenous solid-target assembly has been developed to produce clinical grade 111InCl3 from natCd targets. Fluka Monte Carlo code was used to estimate the optimum proton energy range for 111Cd(p,n)111In production route and suitable decay time to get high specific-activity of 111In. The radiochemical purification and separation have been optimized using column chromatography separation method. The quality of 111InCl3 has been established by radiolabeling of Pentetreotide yielding 111In-Pentetreotide, in acceptable radiochemical purity (RCP), with expected biological efficacy in in-vitro and in-vivo models. Pre-clinical translation of 111InCl3 in formulation of 111In-Pentetreotide adds support toward its use as a clinical grade radiochemical.

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Acknowledgements

The authors gratefully acknowledge the support and encouragement of Director Medical Group BARC, Mumbai, India, towards carrying out this work.

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Authors and Affiliations

  1. Radiation Medicine Centre, Bhabha Atomic Research Centre, TMH Annex, Parel, Mumbai, 400 012, India

    Kanchan Kushwaha, Avik Chakraborty, Megha Tawate, Sangita Lad, Trupti Upadhye, Rahul Bhoite & Sharmila Banerjee

  2. Medical Cyclotron Facility, Board of Radiation and Isotope Technology, Mumbai, India

    Arpit Mitra

  3. Health Physics Division, Bhabha Atomic Research Centre, Mumbai, India

    Biju Keshavkumar

  4. Analytical Chemistry Division, Bhabha Atomic Research Centre, Mumbai, India

    Milan Kumar Dey & Ashis Kumar Satpati

  5. Homi Bhabha National Institute, Mumbai, India

    Kanchan Kushwaha & Sharmila Banerjee

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  1. Kanchan Kushwaha
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Correspondence to Sharmila Banerjee.

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Kushwaha, K., Mitra, A., Chakraborty, A. et al. On the production of pharmaceutical grade indium-111-chloride in the medical cyclotron from natural cadmium target and its use in formulation of diagnostic patient dose of 111In-pentetreotide for imaging somatostatin receptor overexpression. J Radioanal Nucl Chem 328, 835–846 (2021). https://doi.org/10.1007/s10967-021-07652-9

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