13 Result(s)
within
Pierre-Eric Lutz
English
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Article
Open AccessFunctional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies
In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a...
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Article
Open AccessThe basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice
While depression and chronic pain are frequently comorbid, underlying neuronal circuits and their psychopathological relevance remain poorly defined. Here we show in mice that hyperactivity of the neuronal pat...
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Article
Homeorhesis: envisaging the logic of life trajectories in molecular research on trauma and its effects
What sets someone on a life trajectory? This question is at the heart of studies of 21st-century neurosciences that build on scientific models developed over the last 150 years that attempt to link psychopatho...
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Article
Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals
The mu opioid receptor (MOR) is a G protein-coupled receptor that plays an essential role in reward and hedonic processes, and that has been implicated in disorders such as depression and addiction. Over the l...
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Article
Open AccessNon-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation
Early-life adversity (ELA) is a major predictor of psychopathology, and is thought to increase lifetime risk by epigenetically regulating the genome. Here, focusing on the lateral amygdala, a major brain site ...
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Chapter
The Role of Opiates in Social Pain and Suicidal Behavior
With more than 800,000 deaths by suicide each year and 20 to 30 times more suicide attempts worldwide, suicide is a major public health problem. Current treatments of SB are mainly based on pharmacological tre...
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Article
Stalled developmental programs at the root of pediatric brain tumors
Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal pons and forebrain, two major...
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Article
Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides
Glial dysfunction is a major pathophysiological feature of mood disorders. While altered astrocyte (AS) and oligodendrocyte-lineage (OL) functions have been associated with depression, the crosstalk between th...
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Article
Open AccessGlobal long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides
Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed...
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Article
Open AccessMedium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine
Epigenetic modifications of DNA, such as 5-methylcytosine and 5-hydroxymethycytosine, play important roles in development and disease. Here, we present a cost-effective and versatile methodology for the analys...
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Chapter
Targeting Opioid Receptors for Innovative Antidepressant Therapies: Rediscovering the Opioid Cure
The roles of opioid receptors in pain and addiction have been extensively studied, but their function in mood disorders has received less attention. Accumulating evidence from animal research reveals that mu, ...
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Article
Distinct Mu, Delta, and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence
Addiction is a chronic disorder involving recurring intoxication, withdrawal, and craving episodes. Esca** this vicious cycle requires maintenance of abstinence for extended periods of time and is a true cha...
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Article
Open AccessBisQC: an operational pipeline for multiplexed bisulfite sequencing
Bisulfite sequencing is the most efficient single nucleotide resolution method for analysis of methylation status at whole genome scale, but improved quality control metrics are needed to better standardize ex...
