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  1. No Access

    Article

    K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas

    Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique spatiotemporal distributions, partner alterations and molecular profiles. The contribution of the cell of origin to these...

    Selin Jessa, Abdulshakour Mohammadnia, Ashot S. Harutyunyan… in Nature Genetics (2022)

  2. Article

    Open Access

    Latency and interval therapy affect the evolution in metastatic colorectal cancer

    While comparison of primary tumor and metastases has highlighted genomic heterogeneity in colorectal cancer (CRC), previous studies have focused on a single metastatic site or limited genomic testing. Combinin...

    Hamid Nikbakht, Selin Jessa, Mahadeo A. Sukhai, Madeleine Arseneault… in Scientific Reports (2020)

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  3. No Access

    Article

    Stalled developmental programs at the root of pediatric brain tumors

    Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal pons and forebrain, two major...

    Selin Jessa, Alexis Blanchet-Cohen, Brian Krug, Maria Vladoiu… in Nature Genetics (2019)

  4. Article

    Open Access

    Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma

    Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two m...

    Sarah E. Arthur, Aixiang Jiang, Bruno M. Grande, Miguel Alcaide… in Nature Communications (2018)

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