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Article
Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types
The complex relationship between metabolic disease risk and body fat distribution in humans involves cellular characteristics that are specific to body fat compartments. Here we show depot-specific differences...
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Article
Open AccessBisQC: an operational pipeline for multiplexed bisulfite sequencing
Bisulfite sequencing is the most efficient single nucleotide resolution method for analysis of methylation status at whole genome scale, but improved quality control metrics are needed to better standardize ex...
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Article
Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR
Nada Jabado, Jacek Majewski, Annie Huang and colleagues show that embryonal tumors with multilayered rosettes are characterized by a recurrent fusion of TTYH1 with the C19MC microRNA cluster. They further show th...
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Article
Open AccessMutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30 % of HGGs). To identify additional driver mutations in HGGs, we i...
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Article
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
Genome analysis of actinomycetes has revealed the presence of numerous cryptic gene clusters encoding putative natural products1,2. These loci remain dormant until appropriate chemical or physical signals induce ...
