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Article
Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats
Cocaine addiction is a complex pathology inducing long-term neuroplastic changes that, in turn, contribute to maladaptive behaviors. This behavioral dysregulation is associated with transcriptional reprogramm...
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Article
The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: a cluster analysis approach
Increased availability of high-calorie palatable food in most countries has resulted in overconsumption of these foods, suggesting that excessive eating is driven by pleasure, rather than metabolic need. The b...
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Article
Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals
The mu opioid receptor (MOR) is a G protein-coupled receptor that plays an essential role in reward and hedonic processes, and that has been implicated in disorders such as depression and addiction. Over the l...
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Article
Open AccessA mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks
Opioid receptors are G protein-coupled receptors (GPCRs) that modulate brain function at all levels of neural integration, including autonomic, sensory, emotional and cognitive processing. Mu (MOR) and delta (...
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Article
Distinct Mu, Delta, and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence
Addiction is a chronic disorder involving recurring intoxication, withdrawal, and craving episodes. Esca** this vicious cycle requires maintenance of abstinence for extended periods of time and is a true cha...
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Article
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit
The authors use transgenic mice to show that zinc modulates NMDA receptors containing the NR2A subunit, and that this interaction influences pain control in vivo.
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Article
PS III-6
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Article
Opioid receptor random mutagenesis reveals a mechanism for G protein–coupled receptor activation
The high resolution structure of rhodopsin has greatly enhanced current understanding of G protein–coupled receptor (GPCR) structure in the off-state, but the activation process remains to be clarified. We inv...
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Article
Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses
The role of the opioid system in controlling pain1, reward and addiction2,3 is well established, but its role in regulating other emotional responses is poorly documented in pharmacology4. The μ-, δ- and κ- opioi...
