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Article
Open AccessFunctional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies
In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a...
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Article
Open AccessMyc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis
Basal-like breast cancer is a heterogeneous disease characterized by the expression of basal cell markers, no estrogen or progesterone receptor expression and a lack of HER2 ov erexpression. Recent studies hav...
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Article
Open AccessMolecular profiling of patient-derived breast cancer xenografts
Identification of new therapeutic agents for breast cancer (BC) requires preclinical models that reproduce the molecular characteristics of their respective clinical tumors. In this work, we analyzed the genom...
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Article
Open AccessA genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer
The distinction between primary and secondary ovarian tumors may be challenging for pathologists. The purpose of the present work was to develop genomic and transcriptomic tools to further refine the pathologi...
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Article
Open AccessEvaluation of methods for amplification of picogram amounts of total RNA for whole genome expression profiling
For more than a decade, microarrays have been a powerful and widely used tool to explore the transcriptome of biological systems. However, the amount of biological material from cell sorting or laser capture m...
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Article
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays
Ceramide is important in many cell responses, such as proliferation, differentiation, growth arrest and apoptosis. Elevated ceramide levels have been shown to induce apoptosis in primary neuronal cultures and ...
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Protocol
Expression Profiling Using Quantitative Hybridization on Macroarrays
Expression studies performed on a genome scale have become very popular and provide an important link between the sequence and the function of a specific gene, thereby constituting the first step towards the e...
