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Article
Polyamine Participation in the Maturation of Glycoprotein Fucosylation, but not Sialylation, in Rat Small Intestine
The aim of this study was to determine the role of polyamines in the diet-related maturation of the intestinal glycoprotein glycosylation during postnatal development in the rat. The activity of α-2,6-sialyltr...
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Article
Palmitic and Stearic Acids Bind Ca2+ with High Affinity and Form Nonspecific Channels in Black-Lipid Membranes. Possible Relation to Ca2+-Activated Mitochondrial Pores
A mitochondrial hydrophobic component that forms Ca2+-induced nonspecific ion channels in black-lipid membranes (Mironova et al., 1997) has been purified and its nature elucidated. It consists of long-chain satur...
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Chapter and Conference Paper
Food Choice and Health
Kee** up good health, obviously, is connected to a healthy lifestyle. And choosing the right foods is a fundamental element in healthy living. Health maintenance thanks to a very varied daily diet, and possible...
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Article
Study ofO-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid
When treated with retinoic acidin vivo, C6 glioma cells show an enhancement of CMP-Neu5Ac:Galβ 1–3 GalNAc-R α-2,3 sialyltransferase activity. A 300kDa glycoprotein was detected by lectin affinoblotting in retinoi...
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Article
Deletion of arginine (608) in acid sphingomyelinase is the prevalent mutation among Niemann-Pick disease type B patients from northern Africa
There is a high incidence of Niemann-Pick type B disease in the Maghreb region of North Africa, which includes Morocco, Algeria and Tunisia. A hypothesis that there may well be a common, predominant mutant aci...
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Article
Different reactivity of two Brain sialyltransferases towards sulfhydryl reagents. Evidence for a thiol group involved in the nucleotide-sugar binding site of the NeuAcα2-3Galβ1-3GalNAc α(2–6)sialyltransferase
We have studied the amino-acid residues involved in the catalytic activity of two distinct brain sialyltransferases acting on fetuin and asialofetuin. These two enzymes were strongly inhibited byN-bromosuccinimid...
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Article
Biosynthesis of glycoconjugates in mitochondrial outer membranes
The results reported in this paper show two distinct ways for the incorporation ofN-acetylglucosamine into mitochondrial outer membranes. The first one is the glycosylation of dolichol acceptors, which is indicat...
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Chapter
Solubilization of Lipid-Glycosyltransferases from Mitochondrial Outer Membranes
In the mitochondria, the enzymes which catalyze the incorporation of sugars onto lipidic acceptors are intimately associated with membranes. We have previously shown that mitochondrial outer membranes contain ...
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Chapter
Immunological Studies on Acidic Sphingomyelinase
Intrinsic properties of acidic sphingomyelinase cause major difficulties in attempts to produce a satisfactory antibody. The only two published papers do not carry conviction: the monoclonal antibody described...
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Chapter
Sphingomyelinase and Niemann-Pick Disease
Niemann-Pick disease (NPD) is the name given to a group of genetic disorders in which the common feature is a varying degree of sphingomyelin storage in certain tissues. The wide range of clinical heterogeneit...
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Article
Biosynthèse des glycoprotéines dans les cellules infectées par un Arbovirus III. Influence des conditions de la multiplication virale et de la concanavaline A
Glycoprotein biosynthesis in Arbovirus infected cells, during virus multiplication, mannosyl- transferase activity, on endogenous acceptor, is enhanced. A new glycoproteic class appears. Concanavalin A increas...
