Skip to main content

4 Result(s)

within Klaus Ferlinz Remove this filter

and

  1. No Access

    Article

    Characterization of sphingomyelinase activity released by thrombin-stimulated platelets

    In this study we report that human platelets display neutral (nSMase) and acid sphingomyelinase (aSMase) as well as acid ceramidase (aCerase) activity. Cell activation by thrombin resulted in a marked decrease...

    Elena Romiti, Valeria Vasta, Elisabetta Meacci… in Molecular and Cellular Biochemistry (2000)

  2. Article

    Fas/CD95/Apo-I activates the acidic sphingomyelinase via Caspases

    Fas/CD95/Apo-I has been shown to stimulate a variety of molecules including several members of the caspase family and the acidic sphingomyelinase (Martin and Green 1995; Gulbins et al, 1995). Here, we demonstrate...

    Brigit Brenner, Klaus Ferlinz, Heike Grassmé… in Cell Death & Differentiation (1998)

    Download PDF (484 KB)

  3. No Access

    Article

    Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

    Types A and B Niemann–Pick disease (NPD) result from the deficient activity of acid sphingomyelinase (ASM). An animal model of NPD has been created by gene targeting. In affected animals, the disease followed ...

    Kenichi Horinouchi, Shai Erlich, Daniel P. Perl, Klaus Ferlinz… in Nature Genetics (1995)

  4. No Access

    Article

    Deletion of arginine (608) in acid sphingomyelinase is the prevalent mutation among Niemann-Pick disease type B patients from northern Africa

    There is a high incidence of Niemann-Pick type B disease in the Maghreb region of North Africa, which includes Morocco, Algeria and Tunisia. A hypothesis that there may well be a common, predominant mutant aci...

    Marie T. Vanier, Klaus Ferlinz, Robert Rousson, Sylvie Duthel… in Human Genetics (1993)