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Granulomatous interstitial nephritis following BRAF/MEK inhibitor treatment for metastatic melanoma
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Specificity of severe AKI aetiology and care in the elderly. The IRACIBLE prospective cohort study
Acute Kidney Injury (AKI) is increasingly common in people over 65 years of age, but its causes and management are poorly described. The purpose of this study was to describe the causes, management and prognos...
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Characteristics of outpatients referred for a first consultation with a nephrologist: impact of different guidelines
Chronic kidney disease (CKD) affects > 10% of the population but not all CKD patients require referral to a nephrologist. Various recommendations for referral to nephrologists are proposed worldwide. We examin...
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Humanized anti CD-20 as an alternative in chronic management of relapsing thrombotic thrombocytopenic microangiopathy resistant to rituximab due to anti chimeric antibody
Acquired Immune thrombotic thrombocytopenic purpura (iTTP) is considered among clinical situations that needs not only urgent treatment in acute setting but also long term management to prevent relapses. Impor...
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Open AccessPrimary antiphospholipid syndrome associated with anti-phospholipase A2 receptor antibody-positive membranous nephropathy
The kidney is a major target in primary antiphospholipid syndrome. Several types of nephropathy have been reported, the most frequent being acute or chronic specific vascular nephropathies and membranous nephr...
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Anti-MuSK positivity on plasmapheresis liquid in a double seronegative myasthenia gravis patient
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Sirtuins as Markers of Bone Disease: A Focus on Osteoarthritis and Osteoporosis
Sirtuins are widely distributed class III NAD+-dependent histone deacetylases (HDAC) involved in epigenetic regulation. There are seven protein members of the sirtuins, SIRT1-7, each of which specific sites of ac...
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Open AccessBasic science of osteoarthritis
Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic k...
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Living Reference Work Entry In depth
Sirtuins as Markers of Bone Disease: A Focus on Osteoarthritis and Osteoporosis
Sirtuins are widely distributed class III NAD+-dependent histone deacetylases (HDAC) involved in epigenetic regulation. There are seven protein members of the sirtuins, SIRT1-7, each of which specific sites of ac...
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Article
Open AccessHypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts
Bone remodelling and increased subchondral densification are important in osteoarthritis (OA). Modifications of bone vascularization parameters, which lead to ischemic episodes associated with hypoxic conditio...
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Erratum to: Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease 13 - identification of a new biglycan cleavage site
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Open AccessExtracellular localization of galectin-3 has a deleterious role in joint tissues
In this study we examine the extracellular role of galectin-3 (gal-3) in joint tissues. Following intra-articular injection of gal-3 or vehicle in knee joints of mice, histological evaluation of articular cart...
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Chapter
The Role of Bone in the Development of Osteoarthritis
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Article
Open AccessDegradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site
A major and early feature of cartilage degeneration is proteoglycan breakdown. Matrix metalloprotease (MMP)-13 plays an important role in cartilage degradation in osteoarthritis (OA). This MMP, in addition to ...
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Article
Open AccessThe protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases
This study sought to evaluate the levels of mRNA expression and protein synthesis of MMP-13, cathepsin K, aggrecanase-1 (ADAMTS-4), aggrecanase-2 (ADAMTS-5) and 5-lipoxygenase (5-LOX) in cartilage in the exper...
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Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3)
In 1994, a new human matrix metalloproteinase (MMP) was identified and cloned. This enzyme displayed the structural characteristics of a collagenase and was named collagenase-3, or MMP-13 according to MMP nome...
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Study ofO-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid
When treated with retinoic acidin vivo, C6 glioma cells show an enhancement of CMP-Neu5Ac:Galβ 1–3 GalNAc-R α-2,3 sialyltransferase activity. A 300kDa glycoprotein was detected by lectin affinoblotting in retinoi...
