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Article
Formation of Palmitic Acid/Ca2+ Complexes in the Mitochondrial Membrane: A Possible Role in the Cyclosporin-Insensitive Permeability Transition
A possible role of palmitic acid/Ca2+ (PA/Ca2+) complexes in the cyclosporin-insensitive permeability transition in mitochondria has been studied. It has been shown that in the presence of Ca2+, PA induces a swel...
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Article
Palmitic and Stearic Acids Bind Ca2+ with High Affinity and Form Nonspecific Channels in Black-Lipid Membranes. Possible Relation to Ca2+-Activated Mitochondrial Pores
A mitochondrial hydrophobic component that forms Ca2+-induced nonspecific ion channels in black-lipid membranes (Mironova et al., 1997) has been purified and its nature elucidated. It consists of long-chain satur...
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Article
Oscillating Ca2+-Induced Channel Activity Obtained in BLM with a Mitochondrial Membrane Component
Oscillations in ion fluxes and membrane potential may be observed in cells and in mitochondria as well. We obtained Ca2+-induced oscillations in channel activity in black-lipid membranes reconstituted with hydrop...