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Article
Open AccessExpression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation
Extravehicular activities, the backbone of manned space exploration programs, set astronauts into mild hypoxia. Unfortunately, microgravity aggravates threatening symptoms of hypoxia such as vision impairment ...
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Reference Work Entry In depth
Effects of Spaceflight on the Immune System
The immune system belongs to the most affected systems during spaceflight, and sensitivity of cells of the human immune system to reduced gravity has been confirmed in numerous studies in real and simulated mi...
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Article
Open AccessCT-based and morphological comparison of glenoid inclination and version angles and mineralisation distribution in human body donors
For optimal prosthetic anchoring in omarthritis surgery, a differentiated knowledge on the mineralisation distribution of the glenoid is important. However, database on the mineralisation of diseased joints an...
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Chapter and Conference Paper
Climate Change Impact and Vulnerability Analysis in the City of Bratislava: Application and Lessons Learned
Consequences of climate change, like more frequent extreme weather events, are major challenges for urban areas. With diverse approaches for adaptation strategy development available to cities, comparability w...
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Chapter
Cellular and Molecular Responses to Gravitational Force-Triggered Stress in Cells of the Immune System
Sensitivity of the human immune system to microgravity has been supposed since the first Apollo missions and was demonstrated during several space missions in the past. In vitro experiments demonstrated that c...
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Living Reference Work Entry In depth
Effects of Spaceflight on the Immune System
The immune system belongs to the most affected systems during spaceflight, and sensitivity of cells of the human immune system to reduced gravity has been confirmed in numerous studies in real and simulated mi...
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Chapter and Conference Paper
IVAVIA: Impact and Vulnerability Analysis of Vital Infrastructures and Built-Up Areas
This paper presents “Impact and Vulnerability Analysis of Vital Infrastructures and Built-up Areas – IVAVIA”, a standardized process for the assessment of climate change-related risks and vulnerabilities in c...
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Chapter
Risk-Based Analysis of the Vulnerability of Urban Infrastructure to the Consequences of Climate Change
This chapter gives an introduction to risk-based vulnerability assessment of urban infrastructure regarding the consequences of climate change, by describing an approach developed as part of the EU-funded rese...
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Article
Open AccessRapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
The gravitational force has been constant throughout Earth’s evolutionary history. Since the cell nucleus is subjected to permanent forces induced by Earth’s gravity, we addressed the question, if gene express...
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Article
Open AccessStability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4
In the last decades, a plethora of in vitro studies with living human cells contributed a vast amount of knowledge about cellular and molecular effects of microgravity. Previous studies focused mostly on the i...
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Article
Open AccessDynamic gene expression response to altered gravity in human T cells
We investigated the dynamics of immediate and initial gene expression response to different gravitational environments in human Jurkat T lymphocytic cells and compared expression profiles to identify potential...
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Article
Open AccessRapid adaptation to microgravity in mammalian macrophage cells
Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the ce...
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Article
Open AccessGlenoid morphology in light of anatomical and reverse total shoulder arthroplasty: a dissection- and 3D-CT-based study in male and female body donors
Placement of the glenoid baseplate is of paramount importance for the outcome of anatomical and reverse total shoulder arthroplasty. However, the database around glenoid size is poor, particularly regarding sm...
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Article
Open AccessTowards human exploration of space: The THESEUS review series on immunology research priorities
Dysregulation of the immune system occurs during spaceflight and may represent a crew health risk during exploration missions because astronauts are challenged by many stressors. Therefore, it is crucial to un...
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Article
Do regular timetables help to reduce delays in tram networks? It depends!
In public transit planning, regularity of timetables is seen as an important means to improve capacity efficiency by assuring an even trip distribution, as well as to improve product attractiveness and appreci...
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Book
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Chapter
Use of In Vitro Cell Culture Models to Understand the Cellular and Molecular Basis of Immune Dysfunction During Spaceflight
Dysfunction of the immune system is a widely observed phenomenon in astronauts during spaceflight. To study the functional and molecular aspects of spaceflight-induced effects on immune cells, cell culture mod...
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Chapter
Spacecraft Contamination Monitoring and Control
The indoor environmental quality control and thus environmental microbiology in space is very important in order to reduce potential hazards for the crew and the infrastructure, including health hazards of mic...
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Chapter
The Immune System in Space: Are We Prepared? Conclusions, Outlook, and Recommendations
Humans have been traveling to space for more than half a century and have adapted remarkably well to the altered gravity environment. However, several limiting factors for human health and performance in micro...
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Chapter
Spacecraft Microbiology
The immune system is one of the most affected systems of the human body during spaceflights. The microbial environment of a spacecraft consists of numerous microorganisms, many of them pathogenic, as well as s...
