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Reference Work Entry In depth
Effects of Spaceflight on the Immune System
The immune system belongs to the most affected systems during spaceflight, and sensitivity of cells of the human immune system to reduced gravity has been confirmed in numerous studies in real and simulated mi...
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Living Reference Work Entry In depth
Effects of Spaceflight on the Immune System
The immune system belongs to the most affected systems during spaceflight, and sensitivity of cells of the human immune system to reduced gravity has been confirmed in numerous studies in real and simulated mi...
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Article
Open AccessRapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
The gravitational force has been constant throughout Earth’s evolutionary history. Since the cell nucleus is subjected to permanent forces induced by Earth’s gravity, we addressed the question, if gene express...
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Article
Open AccessStability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4
In the last decades, a plethora of in vitro studies with living human cells contributed a vast amount of knowledge about cellular and molecular effects of microgravity. Previous studies focused mostly on the i...
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Article
Open AccessDynamic gene expression response to altered gravity in human T cells
We investigated the dynamics of immediate and initial gene expression response to different gravitational environments in human Jurkat T lymphocytic cells and compared expression profiles to identify potential...
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Chapter
Cellular Effects of Altered Gravity on the Human Adaptive Immune System
Functional deterioration of immune cells has been recorded in real microgravity during spaceflights or parabolic flights and in ground-based facilities in order to simulate microgravity. Numerous in vitro stud...
