-
Article
Open AccessExpression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation
Extravehicular activities, the backbone of manned space exploration programs, set astronauts into mild hypoxia. Unfortunately, microgravity aggravates threatening symptoms of hypoxia such as vision impairment ...
-
Article
Open AccessRapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
The gravitational force has been constant throughout Earth’s evolutionary history. Since the cell nucleus is subjected to permanent forces induced by Earth’s gravity, we addressed the question, if gene express...
-
Article
Open AccessStability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4
In the last decades, a plethora of in vitro studies with living human cells contributed a vast amount of knowledge about cellular and molecular effects of microgravity. Previous studies focused mostly on the i...
-
Article
Open AccessDynamic gene expression response to altered gravity in human T cells
We investigated the dynamics of immediate and initial gene expression response to different gravitational environments in human Jurkat T lymphocytic cells and compared expression profiles to identify potential...
-
Article
Open AccessRapid adaptation to microgravity in mammalian macrophage cells
Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the ce...
-
Chapter
Use of In Vitro Cell Culture Models to Understand the Cellular and Molecular Basis of Immune Dysfunction During Spaceflight
Dysfunction of the immune system is a widely observed phenomenon in astronauts during spaceflight. To study the functional and molecular aspects of spaceflight-induced effects on immune cells, cell culture mod...
-
Chapter
Overview and Translational Impact of Space Cell Biology Research
Space life sciences research is critical to preparation for long-duration space exploration. It is expected that this research will increase our knowledge of basic biological processes, and provide insight int...
-
Chapter
Cellular Effects of Altered Gravity on the Human Adaptive Immune System
Functional deterioration of immune cells has been recorded in real microgravity during spaceflights or parabolic flights and in ground-based facilities in order to simulate microgravity. Numerous in vitro stud...
-
Chapter
Immune Dysfunction in Spaceflight: An Integrative View
Physical or psychological stress in space is one of the major concerns for the health of space travelers. The critical stress factors, especially during long-duration spaceflight missions, consist of stressors...
-
Chapter
Cellular Effects of Altered Gravity on the Innate Immune System and the Endothelial Barrier
To protect the human body from pathogens the innate immune system is of central importance. Different specialized cell types fight intruding pathogens as a first line of defense. Another cell type involved in ...
-
Article
Open AccessSignal transduction in primary human T lymphocytes in altered gravity – results of the MASER-12 suborbital space flight mission
We investigated the influence of altered gravity on key proteins of T cell activation during the MASER-12 ballistic suborbital rocket mission of the European Space Agency (ESA) and the Swedish Space Cooperatio...
-
Article
Open AccessRapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
In our study we aimed to identify rapidly reacting gravity-responsive mechanisms in mammalian cells in order to understand if and how altered gravity is translated into a cellular response. In a combination of...
-
Article
Open AccessThe cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins
In this study we investigated if and how cannabinoid receptor stimulation regulates macrophageal differentiation, which is one of the key steps in the immune effector reaction. For that reason, we used a well ...
-
Article
Open AccessCannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
Adult neurogenesis is a particular example of brain plasticity that is partially modulated by the endocannabinoid system. Whereas the impact of synthetic cannabinoids on the neuronal progenitor cells has been ...
