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Article
Open AccessErythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation
Myelination is a process tightly regulated by a variety of neurotrophic factors. Here, we show—by analyzing two transgenic mouse lines, one overexpressing EPO selectively in the brain Tg21(PDGFB-rhEPO) and anothe...
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Article
Open AccessExpression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation
Extravehicular activities, the backbone of manned space exploration programs, set astronauts into mild hypoxia. Unfortunately, microgravity aggravates threatening symptoms of hypoxia such as vision impairment ...
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Article
Open AccessEndogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice
Myoglobin (MB) is expressed in different cancer types and may act as a tumor suppressor in breast cancer. The mechanisms by which basal MB expression level impacts murine mammary tumorigenesis are unclear. We ...
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Article
Open AccessErythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice
Erythropoietin (EPO) improves neuronal mitochondrial function and cognition in adults after brain injury and in those afflicted by psychiatric disorders. However, the influence of EPO on mitochondria and cogni...
