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Article
(R)-GEMOX chemotherapy for unfit patients with refractory or recurrent primary central nervous system lymphoma: a LOC study
Recurrent primary central nervous system lymphomas (PCNSL) have a very poor prognosis. For young and fit patients, intensive chemotherapy followed by autologous stem cell transplantation could be proposed at r...
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Article
IDH mutation is paradoxically associated with higher 18F-FDOPA PET uptake in diffuse grade II and grade III gliomas
The World Health Organization Classification of Tumors of the Central Nervous System has recently been updated by the integration of diagnostic and prognostic molecular parameters, giving pivotal attention to IDH
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Article
Co** with a newly diagnosed high-grade glioma: patient-caregiver dyad effects on quality of life
Patients with high-grade gliomas (HGG) and their caregivers have to confront a very aggressive disease that produces major lifestyle disruptions. There is an interest in studying the ability of patients and th...
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Article
Neuro-oncological patients admitted in intensive-care unit: predictive factors and functional outcome
The prognosis of oncology patients admitted to the intensive care unit (ICU) is considered poor. Our objective was to analyze the characteristics and predictive factors of death in the ICU and functional outco...
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Article
Limited impact of prognostic factors in patients with recurrent glioblastoma multiforme treated with a bevacizumab-based regimen
Bevacizumab has demonstrated activity in patients with recurrent glioblastoma. However, the impact of prognostic factors associated with recurrent glioblastoma treated with cytotoxic agents has not been determ...
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Article
Glioblastomes: aspects moléculaires et prise en charge actuelle
Glioblastomas are the kind of malignant gliomas found most frequently in adults. In nearly all glioblastomas there is activation of the receptor tyrosine-kinase pathway and deactivation of the p53 and retinobl...
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Article
Identification of secondary structure in the 5′-untranslated region of the human adrenomedullin mRNA with implications for the regulation of mRNA translation
Adrenomedullin (AM) is a multifunctional regulatory peptide with important angiogenic and mitogenic properties. Here we identify a region of stable secondary structure in the 5′-untranslated region (5′ UTR) of...
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Article
The role of Gamma Knife radiosurgery in the treatment of pineal parenchymal tumours
Object. The aim of this study was to document the possible role of Gamma Knife radiosurgery, suitable for the treatment of deep and well limited tumors, in the management of pineal parenchymal tumors (PPT).
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Article
Open AccessSummary version of the Standards, Options and Recommendations for the management of adult patients with intracranial glioma (2002)
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Article
Open AccessClinical implications of quantitative real-time RT–PCR analysis of hTERT gene expression in human gliomas
The presence of telomerase activity in a glioma may be a predictor of its malignant potential. Activation of telomerase is regulated at the transcriptional level of the human telomerase reverse transcriptase (hTE...
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Chapter
Surgical management
Surgical debulking is a part of therapy for intracranial malignant brain tumors. A radical resection of the neoplasm, in general, offers a better prognosis for patients with gliomas. Similarly, a greater resec...
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Article
Abstracts of posters
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Article
Prognostic value of cytosolic tyrosine kinase activity in 249 node-positive breast cancer patients
Tyrosine-specific protein kinase (TPK) has been associated with the cytoplasmic domain of growth factor receptors as well as oncoproteins. Enzymatic activation appears to be a major initial event in these sign...
