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  1. Article

    Open Access

    Epstein-Barr virus as a marker of biological aggressiveness in breast cancer

    Although a potential role of the Epstein-Barr virus (EBV) in the pathogenesis of breast cancer (BC) has been underlined, results remain conflicting. Particularly, the impact of EBV infection on biological mark...

    C Mazouni, F Fina, S Romain, L Ouafik, P Bonnier, J-M Brandone… in British Journal of Cancer (2011)

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  2. No Access

    Article

    Relations du système plasminogène-plasmine et cancer

    Proteases play a central role in tissue repair and in the process of tumour growth and invasiveness. However, almost all of the proteolytic enzymes are secreted as inactive pro-proteases. With the exception of...

    P.-M. Martin, C. Dussert, S. Romain, L.H. Ouafik in Oncologie (2010)

  3. Article

    Open Access

    Determination of TGFβ1 protein level in human primary breast cancers and its relationship with survival

    Transforming growth factor-beta (TGFβ)1 is thought to be implicated in breast cancer progression. However, data about the influence of TGFβ1 on breast cancer development are conflicting. To clarify the clinical r...

    S Desruisseau, J Palmari, C Giusti, S Romain, P-M Martin… in British Journal of Cancer (2006)

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  4. Article

    Open Access

    Frequency and genome load of Epstein-Barr virus in 509 breast cancers from different geographical areas

    Since the few data exploring a possible association between Epstein–Barr virus (EBV) and breast cancer are conflicting, we investigated this association together with the influences of geographical areas. 509 ...

    F Fina, S Romain, L'H Ouafik, J Palmari, F Ben Ayed… in British Journal of Cancer (2001)

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  5. Article

    Open Access

    Prognostic value of uPA and p53 accumulation measured by quantitative biochemical assays in 1245 primary breast cancer patients: a multicentre study

    The purpose of this retrospective multicentre study was to assess the prognostic value of urokinase plasminogen activator (uPA) and p53 levels in a large series of primary breast cancer, using an automatic qua...

    P Broët, F Spyratos, S Romain, V Quillien, A Daver… in British Journal of Cancer (1999)

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  6. No Access

    Article

    Prognostic value of cytosolic tyrosine kinase activity in 249 node-positive breast cancer patients

    Tyrosine-specific protein kinase (TPK) has been associated with the cytoplasmic domain of growth factor receptors as well as oncoproteins. Enzymatic activation appears to be a major initial event in these sign...

    S Romain, O Chinot, JGM Klijn, WLJ van Putten, O Guirou… in British Journal of Cancer (1994)

  7. No Access

    Article

    Prognostic value of a solubilized fraction of EGF receptors in primary breast cancer using an immunoenzymatic assay — a retrospective study

    In a retrospective study of 319 primary breast cancers, we show that an immunoenzymatic assay of a solubilized fraction of EGF receptors indicates a prognostic value for EGFR which is in contradiction with som...

    F. Spyratos, P. M. Martin, K. Hacène, C. Andrieu… in Breast Cancer Research and Treatment (1994)

  8. No Access

    Article

    Prognostic value of epidermal growth factor receptor in node-positive breast cancer

    The prognostic significance of EGFR (epidermal growth factor receptor) was studied in a cohort of 68 node-positive patients with breast cancer, who entered a controlled protocol of adjuvant therapy between Feb...

    M. Grimaux, S. Romain, Y. Remvikos, P. M. Martin… in Breast Cancer Research and Treatment (1989)