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  1. Article

    Open Access

    Interleukin-6 gene amplification and shortened survival in glioblastoma patients

    Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were det...

    A Tchirkov, T Khalil, E Chautard, K Mokhtari, L Véronèse… in British Journal of Cancer (2007)

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  2. No Access

    Article

    High-dose BCNU followed by autologous hematopoietic stem cell transplantation in supratentorial high-grade malignant gliomas: a retrospective analysis of 114 patients

    Conventional treatment of high-grade glioma includes maximal surgical resection followed by external radiation therapy. Despite this treatment, the prognosis for patients is poor. High doses of chemotherapy mi...

    X Durando, J-J Lemaire, J Tortochaux, I Van-Praagh… in Bone Marrow Transplantation (2003)

  3. Article

    Open Access

    Clinical implications of quantitative real-time RT–PCR analysis of hTERT gene expression in human gliomas

    The presence of telomerase activity in a glioma may be a predictor of its malignant potential. Activation of telomerase is regulated at the transcriptional level of the human telomerase reverse transcriptase (hTE...

    A Tchirkov, C Rolhion, J-L Kémény, B Irthum, S Puget, T Khalil… in British Journal of Cancer (2003)

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  4. No Access

    Article

    Slow Pressure Waves in the Cranial Enclosure

    J. J. Lemaire, T. Khalil, F. Cervenansky, G. Gindre, J. Y. Boire… in Acta Neurochirurgica (2002)

  5. No Access

    Article

    Direct Stereotactic MRI Location in the Globus Pallidus for Chronic Stimulation in Parkinson's Disease

     We evaluated the direct location in the globus pallidus (GP) under stereotactic MRI (sMRI) guidance in five parkinsonians treated with chronic deep brain stimulation (four bilaterally). The sMRI consisted of ...

    J. J. Lemaire, F. Durif, J. Y. Boire, B. Debilly, B. Irthum… in Acta Neurochirurgica (1999)

  6. No Access

    Chapter

    Evaluation of Stereotactic Biopsy as an aid to the Management of Supratentorial Tumors:

    The purpose of this study is to evaluate the advantages brought about by the use of stereotactic biopsies in the treatment of cerebral tumors and especially to appreciate wether the precise knowledge of the na...

    B. Irthum, J. Chazal, M. Mohr, A. M. Georget… in Brain Oncology Biology, diagnosis and ther… (1987)

  7. No Access

    Article

    Dilatation of the subarachnoid pericerebral space and absorption of cerebrospinal fluid in the infant

    The authors investigated intracranial pressure, resistance to cerebrospinal fluid (CSF) absorption following ventricular infusion and radiopharmaceutical absorption of radionuclide injected into the ventricles...

    J. Chazal, A. Tanguy, B. Irthum, P. Janny, G. Vanneuville in Anatomia Clinica (1985)