15 Result(s)

Article

Author Correction: Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth

Camilla Tombari, Alessandro Zannini, Rebecca Bertolio… in Nature Communications (2023)

Article

Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth

Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 oncoproteins stimulate de no...

Camilla Tombari, Alessandro Zannini, Rebecca Bertolio… in Nature Communications (2023)

Article

Spinocerebellar ataxia 38: structure–function analysis shows ELOVL5 G230V is proteotoxic, conformationally altered and a mutational hotspot

Fatty acid elongase ELOVL5 is part of a protein family of multipass transmembrane proteins that reside in the endoplasmic reticulum where they regulate long-chain fatty acid elongation. A missense variant (c.6...

Enza Ferrero, Eleonora Di Gregorio, Marta Ferrero, Erika Ortolan… in Human Genetics (2023)

Article

Bicalutamide and Trehalose Ameliorate Spinal and Bulbar Muscular Atrophy Pathology in Mice

Spinal and bulbar muscular atrophy (SBMA) is characterized by motor neuron (MN) degeneration that leads to slowly progressive muscle weakness. It is considered a neuromuscular disease since muscle has a primar...

Mariarita Galbiati, Marco Meroni, Marina Boido, Matilde Cescon… in Neurotherapeutics (2023)

Article

Changes in the lipidome of water buffalo milk during intramammary infection by non-aureus Staphylococci

This study aimed to determine the lipidome of water buffalo milk with intramammary infection (IMI) by non-aureus staphylococci (NAS), also defined as coagulase-negative staphylococci, using an untargeted lipid...

Fabrizio Ceciliani, Matteo Audano, Maria Filippa Addis, Nico Mitro… in Scientific Reports (2022)

Article

Metabolomic signature and mitochondrial dynamics outline the difference between vulnerability and resilience to chronic stress

Stress is the foremost environmental factor involved in the pathophysiology of major depressive disorder (MDD). However, individual differences among people are critical as some people exhibit vulnerability wh...

Paola Brivio, Matteo Audano, Maria Teresa Gallo, Piotr Gruca… in Translational Psychiatry (2022)

Article

Author Correction: The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites

Camilla Bean, Matteo Audano, Tatiana Varanita, Francesca Favaretto… in Nature Metabolism (2022)

Article

Ca²⁺ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells

Melanoma is an aggressive tumor with still poor therapy outcomes. δ-tocotrienol (δ-TT) is a vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated that δ-TT triggers apoptos...

Michela Raimondi, Fabrizio Fontana, Monica Marzagalli, Matteo Audano… in Apoptosis (2021)

Article

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metab...

Chiara Milanese, Cíntia R. Bombardieri, Sara Sepe… in Nature Communications (2019)

Article

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells ...

Fabrizia Bonacina, David Coe, Guosu Wang, Maria P. Longhi… in Nature Communications (2018)

Article

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features

Disruption of axonal transport plays a pivotal role in diabetic neuropathy. A sex-dimorphism exists in the incidence and symptomatology of diabetic neuropathy; however, no studies so far have addressed sex dif...

Marzia Pesaresi, Silvia Giatti, Roberto Spezzano… in Biology of Sex Differences (2018)

Article

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response to environmental stimuli such as cold. Post-translational modifications of histones have been shown to regulate cellul...

Alessandra Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva… in Nature Communications (2017)

Article

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenv...

Barbara Castella, Joanna Kopecka, Patrizia Sciancalepore… in Nature Communications (2017)

Article

Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstra...

Valeria Benedusi, Sara Della Torre, Nico Mitro, Donatella Caruso… in Scientific Reports (2017)

Article

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function

Nico Mitro, Gaia Cermenati, Matteo Audano, Silvia Giatti… in SpringerPlus (2015)