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Open AccessASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity
Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins, including lipoproteins, from the circulation. In humans, loss-of-function...
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Article
Open AccessThe glucose transporter 2 regulates CD8+ T cell function via environment sensing
T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagem...
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Metabolomics, Lipidomics, and Immunometabolism
Metabolomics, lipidomics, and the study of cellular metabolism are gaining increasing interest particularly in the field of immunology, since the activation and effector functions of immune cells are profoundl...
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Article
The Interconnection Between Immuno-Metabolism, Diabetes, and CKD
Metabolic reprogramming is increasingly recognized as an essential trait of functional activation of immune cells. Here, we describe the link between immuno-metabolism, diabetes, and diabetic nephropathy.
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Article
Open AccessAuthor Correction: Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessMyeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells ...
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Article
Open AccessCluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans
Ex vivo expansion and differentiation of human pancreatic β-cell are enabling steps of paramount importance for accelerating the development of therapies for diabetes. The success of regenerative strategies depen...
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Article
The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis
Atherosclerosis is an inflammatory disorder of the arterial wall, in which several players contribute to the onset and progression of the disease. Besides the well-established role of lipids, specifically chol...
