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Open AccessAuthor Correction: Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
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Open AccessMutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 oncoproteins stimulate de no...
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Open AccessSterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholest...
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Article
Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis
Tumour-associated p53 missense mutants act as driver oncogenes affecting cancer progression, metastatic potential and drug resistance (gain-of-function) 1 . Mutant p53 protein st...
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Open AccessGlucocorticoid receptor signalling activates YAP in breast cancer
The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activat...
