26 Result(s)

Article

The 5-HT_1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models

NLX-101 and NLX-204 are highly selective serotonin 5-HT_1A ‘biased’ agonists, displaying potent and efficacious antidepressant-like activity upon acute administration in models such as the forced swim test.

Mariusz Papp, Piotr Gruca, Magdalena Lason, Ewa Litwa… in Psychopharmacology (2023)

Article

Resilience to chronic mild stress-induced anhedonia preserves the ability of the ventral hippocampus to respond to an acute challenge

Stress is a major precipitating factor for psychiatric disorders and its effects may depend on its duration and intensity. Of note, there are differences in individual susceptibility to stress, with some subje...

Paola Brivio, Maria Teresa Gallo… in European Archives of Psychiatry and Clinic… (2023)

Article

Metabolomic signature and mitochondrial dynamics outline the difference between vulnerability and resilience to chronic stress

Stress is the foremost environmental factor involved in the pathophysiology of major depressive disorder (MDD). However, individual differences among people are critical as some people exhibit vulnerability wh...

Paola Brivio, Matteo Audano, Maria Teresa Gallo, Piotr Gruca… in Translational Psychiatry (2022)

Article

The effects of agomelatine and imipramine on liver cytochrome P450 during chronic mild stress (CMS) in the rat

The aim of our research was to determine the effects of chronic treatment with the atypical antidepressant agomelatine on the expression and activity of liver cytochrome P450 (CYP) in the chronic mild stress (...

Anna Haduch, Ewa Bromek, Marta Rysz, Renata Pukło, Mariusz Papp… in Pharmacological Reports (2020)

Article

The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats

A growing body of evidence suggests that depression may be associated with impairment of the tryptophan catabolites (TRYCATs) pathway. The present study investigated the effects of the chronic administration o...

Paulina Wigner, Ewelina Synowiec, Paweł Jóźwiak… in Journal of Molecular Neuroscience (2020)

Article

Resilient Phenotype in Chronic Mild Stress Paradigm Is Associated with Altered Expression Levels of miR-18a-5p and Serotonin 5-HT_1a Receptor in Dorsal Part of the Hippocampus

Disturbed serotonergic signaling in the hippocampus observed in many individuals vulnerable to stress has been suggested as one of the primary factors contributing to the development of depression. However, li...

Dariusz Zurawek, Piotr Gruca, Lucyna Antkiewicz-Michaluk… in Molecular Neurobiology (2019)

Article

Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat

The role of somatostatin and its receptors for the stress-related neuropsychiatric disorders has been widely raised. Recently, we have also demonstrated the involvement of somatostatin receptor type 2-sst2R an...

Agata Faron-Górecka, Maciej Kuśmider, Joanna Solich, Magdalena Kolasa… in Psychopharmacology (2018)

Article

Reciprocal MicroRNA Expression in Mesocortical Circuit and Its Interplay with Serotonin Transporter Define Resilient Rats in the Chronic Mild Stress

Prolonged stress perturbs physiological balance of a subject and thus can lead to depression. Nevertheless, some individuals are more resilient to stress than the others. Defining molecular factors underlying ...

Dariusz Zurawek, Maciej Kusmider, Agata Faron-Gorecka… in Molecular Neurobiology (2017)

Article

Dopaminergic mechanisms in memory consolidation and antidepressant reversal of a chronic mild stress-induced cognitive impairment`

Cognitive deficits in depression can be modelled using the novel object recognition (NOR) test, performance in which is impaired by chronic mild stress (CMS). We aimed to examine the involvement of mesocortico...

Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Ewa Litwa… in Psychopharmacology (2017)

Article

The Effect of Chronic Mild Stress and Imipramine on the Markers of Oxidative Stress and Antioxidant System in Rat Liver

Liver abnormalities have been reported to occur in up to 20 % of patients on a long-term therapy with the tricyclic antidepressant drug imipramine (IMI). The mechanism involved in this IMI-induced process is u...

Weronika Duda, Katarzyna Curzytek, Marta Kubera, Małgorzata Iciek… in Neurotoxicity Research (2016)

Article

Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats

The treatment of depression in old age is complicated by frequent co-morbidity with cognitive impairment. Anti-dementia drugs have some efficacy to improve cognitive performance and there is an inconsistent li...

Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Paul Willner in Psychopharmacology (2016)

Article

The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT_1A receptor signaling: mechanistic studies

Diverse preclinical studies suggest the potential therapeutic utility of the modulation of the glutamatergic system in brain via metabotropic glutamate (mGlu) receptors. Lu AF21934, a positive allosteric modul...

Joanna M. Wierońska, Anna Sławińska, Magdalena Łasoń-Tyburkiewicz… in Psychopharmacology (2015)

Article

The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT_1A signalling

Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new way to achieve antipsychotic-like activity. LSP1-2111, the group III mGlu r...

Joanna M. Wierońska, Francine C. Acher, Anna Sławińska, Piotr Gruca… in Psychopharmacology (2013)

Article

Mesolimbic dopamine D₂ receptor plasticity contributes to stress resilience in rats subjected to chronic mild stress

Few studies have investigated neurobiological and biochemical differences between stress-resilient and stress-vulnerable experimental animals.

Dariusz Żurawek, Agata Faron-Górecka, Maciej Kuśmider… in Psychopharmacology (2013)

Article

Alterations in number and functions of lymphocytes after exposure to chronic mild stress: the effect of desipramine

Beata Grygier, Marta Kubera, Danuta Wrona, Piotr Gruca… in Pharmacological Reports (2012)

Article

mGlu4-dependent reversal of the MK-801-induced cognitive impartment involves 5-HT1A receptors

Joanna M. Wieroñska, Andrzej Pilc, Dario Doller, Piotr Gruca… in Pharmacological Reports (2012)