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  1. Article

    Open Access

    The effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients

    The role of exercise in cancer prevention and control is increasingly recognized, and based on preclinical studies, it is hypothesized that mobilization of leukocytes plays an important role in the anti-tumor ...

    Tiia Koivula, Salla Lempiäinen, Petteri Rinne, Jenna H. Rannikko in Scientific Reports (2023)

  2. Article

    Open Access

    The tumor and plasma cytokine profiles of renal cell carcinoma patients

    Renal cell carcinoma (RCC) accounts for 90% of all renal cancers and is considered highly immunogenic. Although many studies have reported the circulating peripheral cytokine profiles, the signatures between t...

    Moon Hee Lee, Essi Laajala, Anna Kreutzman, Petrus Järvinen in Scientific Reports (2022)

  3. Article

    Open Access

    Red blood cell transfusion induces abnormal HIF-1α response to cytokine storm after adult cardiac surgery

    Patients undergoing cardiac surgery develop a marked postoperative systemic inflammatory response. Blood transfusion may contribute to disruption of homeostasis in these patients. We sought to evaluate the imp...

    Emma Viikinkoski, Juho Jalkanen, Jarmo Gunn, Tuija Vasankari in Scientific Reports (2021)

  4. Article

    Open Access

    Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology

    Lipedema is a chronic adipose tissue disorder characterized by the disproportional subcutaneous deposition of fat and is commonly misdiagnosed as lymphedema or obesity. The molecular determinants of the lipede...

    Gunther Felmerer, Aikaterini Stylianaki, Maija Hollmén in Scientific Reports (2020)

  5. Article

    Open Access

    Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice

    Obesity comprises great risks for human health, contributing to the development of other diseases such as metabolic syndrome, type 2 diabetes and cardiovascular disease. Previously, obese patients were found t...

    Sinem Karaman, Maija Hollmén, Sun-Young Yoon, H. Furkan Alkan in Scientific Reports (2016)

  6. Article

    Open Access

    Characterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer

    Tumor heterogeneity may broadly influence the activation of tumor-associated macrophages. We aimed to dissect how breast cancer cells of different molecular characteristics contribute to macrophage phenotype a...

    Maija Hollmén, Filip Roudnicky, Sinem Karaman, Michael Detmar in Scientific Reports (2015)

  7. Article

    Open Access

    Fingerprinting Breast Cancer vs. Normal Mammary Cells by Mass Spectrometric Analysis of Volatiles

    There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile met...

    **g**g He, Pablo Martinez-Lozano Sinues, Maija Hollmén, Xue Li in Scientific Reports (2014)