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  1. No Access

    Article

    Incidence of components of metabolic syndrome in the metabolically healthy obese over 9 years follow-up: the Atherosclerosis Risk In Communities study

    Some obese adults are not afflicted by the metabolic abnormalities often associated with obesity (the ‘metabolically healthy obese’ (MHO)); however, they may be at increased risk of develo** cardiometabolic ...

    P T Bradshaw, K R Reynolds, L E Wagenknecht… in International Journal of Obesity (2018)

  2. Article

    Open Access

    Associations of coffee consumption with markers of liver injury in the insulin resistance atherosclerosis study

    Coffee consumption has been associated with reduced risk of develo** type 2 diabetes mellitus (T2DM) however, the mechanism for this association has yet to be elucidated. Non-alcoholic fatty liver disease (N...

    J. C. Dickson, A. D. Liese, C. Lorenzo, S. M. Haffner… in BMC Gastroenterology (2015)

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  3. No Access

    Article

    FTO predicts weight regain in the Look AHEAD clinical trial

    Genome-wide association studies have provided new insights into the genetic factors that contribute to the development of obesity. We hypothesized that these genetic markers would also predict magnitude of wei...

    J M McCaffery, G D Papandonatos, G S Huggins, I Peter… in International Journal of Obesity (2013)

  4. Article

    The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS)

    Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impair...

    C. C. Lee, C. Lorenzo, S. M. Haffner, L. E. Wagenknecht, A. Festa… in Diabetologia (2013)

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  5. No Access

    Article

    Implication of European-derived adiposity loci in African Americans

    Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Ameri...

    J M Hester, M R Wing, J Li, N D Palmer, J Xu, P J Hicks… in International Journal of Obesity (2012)

  6. Article

    Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)

    Associations of proinsulin-to-insulin ratios with incident type 2 diabetes have been inconsistent. The use of C-peptide as the denominator in the ratio may allow for better prediction because C-peptide concent...

    R. C. Loopstra-Masters, S. M. Haffner, C. Lorenzo, L. E. Wagenknecht… in Diabetologia (2011)

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  7. No Access

    Article

    Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort

    Previous studies have replicated the association of variants within FTO (fat mass- and obesity-associated) intron 1 with obesity and adiposity quantitative traits in populations of European ancestry. Non-European...

    M R Wing, J M Ziegler, C D Langefeld, B H Roh… in International Journal of Obesity (2011)

  8. Article

    Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function

    Although protective relationships between coffee consumption and type 2 diabetes mellitus have consistently been observed, few studies have examined the relationships between coffee consumption and underlying ...

    R. C. Loopstra-Masters, A. D. Liese, S. M. Haffner, L. E. Wagenknecht… in Diabetologia (2011)

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  9. Article

    Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose

    Elevated fasting NEFAs are thought to promote type 2 diabetes. Three prospective studies support this concept, showing increased diabetes risk associated with fasting NEFA. However, these prospective associati...

    D. Il’yasova, F. Wang, R. B. D’Agostino Jr, A. Hanley, L. E. Wagenknecht in Diabetologia (2010)

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  10. Article

    Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study

    Central obesity, insulin resistance and beta cell dysfunction are independent risk factors for incident type 2 diabetes, although few studies have used detailed measures of these disorders. Our objective was t...

    A. J. G. Hanley, L. E. Wagenknecht, J. M. Norris, M. Bryer-Ash, Y. I. Chen… in Diabetologia (2009)

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  11. Article

    A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)

    This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American partic...

    S. S. Rich, M. O. Goodarzi, N. D. Palmer, C. D. Langefeld, J. Ziegler… in Diabetologia (2009)

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  12. No Access

    Article

    Genetic map** of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study

    Obesity is widely accepted to be influenced by both environmental and genetic factors. Several recent studies have used the positional cloning approach in an attempt to discover genes contributing to obesity. ...

    B S Sutton, C D Langefeld, J K Campbell, S M Haffner… in International Journal of Obesity (2006)

  13. Article

    The impact of ethnicity and sex on subclinical cardiovascular disease: the Diabetes Heart Study

    African–Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subcl...

    B. I. Freedman, F. C. Hsu, C. D. Langefeld, S. S. Rich, D. M. Herrington… in Diabetologia (2005)

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  14. No Access

    Article

    Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study

    Adipose tissue distribution (visceral vs subcutaneous) has been shown to be an important predictor of insulin resistance, diabetes and cardiovascular disease, independent of body mass index. The beta-2 adrenergic...

    L A Lange, J M Norris, C D Langefeld, B J Nicklas… in International Journal of Obesity (2005)

  15. No Access

    Article

    Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family Study

    To conduct linkage analysis for body mass index (BMI, kg/m2), waist-to-hip ratio (WHR), visceral adipose tissue mass (VAT, cm2) and subcutaneous adipose tissue mass (SAT, cm2) using a whole genome scan.

    J M Norris, C D Langefeld, A L Scherzinger, S S Rich… in International Journal of Obesity (2005)

  16. No Access

    Article

    Insulin resistance and weight gain in postmenopausal women of diverse ethnic groups

    OBJECTIVE: This study was conducted to examine the influence of insulin resistance on weight change in postmenopausal women of various ethnic groups.

    B V Howard, L Adams-Campbell, C Allen, H Black… in International Journal of Obesity (2004)