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  1. No Access

    Article

    Efficient expression of bioactive murine IL12 as a self-processing P2A polypeptide driven by inflammation-regulated promoters in tumor cell lines

    Interleukin 12 (IL12) is a heterodimeric proinflammatory cytokine that has shown promise as an anticancer agent. However, despite encouraging results in animal models, clinical trials involving IL12 have been ...

    C Lorenzo, G Pérez-Chacón, G Garaulet, Z Mallorquín, J M Zapata… in Cancer Gene Therapy (2015)

  2. Article

    Open Access

    Associations of coffee consumption with markers of liver injury in the insulin resistance atherosclerosis study

    Coffee consumption has been associated with reduced risk of develo** type 2 diabetes mellitus (T2DM) however, the mechanism for this association has yet to be elucidated. Non-alcoholic fatty liver disease (N...

    J. C. Dickson, A. D. Liese, C. Lorenzo, S. M. Haffner… in BMC Gastroenterology (2015)

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  3. No Access

    Article

    Predicting the development of the metabolically healthy obese phenotype

    The metabolically healthy (MHO) and unhealthy obese (MUHO) differ in terms of cardiovascular risk. However, little is known about predicting the development of these phenotypes and the future stability of the ...

    I Achilike, H P Hazuda, S P Fowler, K Aung, C Lorenzo in International Journal of Obesity (2015)

  4. Article

    The association of alanine aminotransferase within the normal and mildly elevated range with lipoproteins and apolipoproteins: the Insulin Resistance Atherosclerosis Study

    Markers of liver injury, such as alanine aminotransferase (ALT), have been associated with atherogenic lipoprotein changes. We examined the extent to which this association was explained by insulin resistance,...

    C. Lorenzo, A. J. Hanley, M. J. Rewers, S. M. Haffner in Diabetologia (2013)

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  5. Article

    The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS)

    Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impair...

    C. C. Lee, C. Lorenzo, S. M. Haffner, L. E. Wagenknecht, A. Festa… in Diabetologia (2013)

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  6. Article

    Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)

    Associations of proinsulin-to-insulin ratios with incident type 2 diabetes have been inconsistent. The use of C-peptide as the denominator in the ratio may allow for better prediction because C-peptide concent...

    R. C. Loopstra-Masters, S. M. Haffner, C. Lorenzo, L. E. Wagenknecht… in Diabetologia (2011)

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  7. Article

    Risk of type 2 diabetes among individuals with high and low glomerular filtration rates

    Metabolic abnormalities frequently develop prior to the diagnosis of type 2 diabetes and chronic kidney disease. However, it is not known whether GFR predicts the onset of type 2 diabetes.

    C. Lorenzo, S. D. Nath, A. J. G. Hanley, H. E. Abboud, J. A. L. Gelfond… in Diabetologia (2009)

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  8. Article

    A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis

    The cellular level of the CDC25A phosphatase is tightly regulated during both the normal and genotoxic-perturbed cell cycle. Here, we describe a caspase-dependent cleavage of this protein at residue D223 in no...

    A Mazars, A Fernandez-Vidal, O Mondesert, C Lorenzo… in Cell Death & Differentiation (2009)

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  9. No Access

    Article

    Differential mitotic degradation of the CDC25B phosphatase variants

    CDC25 phosphatases control cell-cycle progression by dephosphorylating and activating cyclin-dependent kinases. CDC25B, one of the three members of this family in human cells, is thought to regulate initial mi...

    I Kieffer, C Lorenzo, C Dozier, E Schmitt, B Ducommun in Oncogene (2007)

  10. Article

    40th EASD Annual Meeting of the European Association for the Study of Diabetes

    M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

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  11. No Access

    Article

    The Omiltemi rabbit (Sylvilagus insonus) is not extinct

    F. A. Cervantes, C. Lorenzo, F. X. González-Cózatl in Mammalian Biology (2004)

  12. No Access

    Article

    The Atapuerca human fossils

    After 20 years of research, the Atapuerca sites have provided a large amount of archaeological and palaeontological remains. Human fossils have been found in three sites: Gran Dolina, galería and Sima de los H...

    J. L. Arsuaga, C. Lorenzo, I. Martínez, A. Gracia, J. M. Carretero… in Human Evolution (2000)

  13. Article

    ALTERED MONONUCLEAR CELL IMMUNE RESPONSE IN WOMEN EXPOSED TO DES IN UTERO

    In utero diethylstilbestrol (DES) exposure results in long term reproductive consequences. Preliminary evidence suggests a link between prenatal DES exposure and long term alterations in the immune system. To ...

    M Seqall-Blank, L Burke, C Lorenzo, D Trentham, J Mortola in Pediatric Research (1993)

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