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Article
In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells
Future deep space missions to Mars and near-Earth asteroids will expose astronauts to chronic solar energetic particles (SEP) and galactic cosmic ray (GCR) radiation, and likely one or more solar particle even...
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Article
Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study
A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human
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Article
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation of multiple organ systems and dysregulated interferon responses. SLE is both genetically and phenotypically het...
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Article
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region
In a genome-wide association study (GWAS) of individuals of European ancestry afflicted with systemic lupus erythematosus (SLE) the extensive utilization of imputation, step-wise multiple regression, lasso reg...
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Article
Open AccessMHC associations with clinical and autoantibody manifestations in European SLE
Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to nuclear components. Although genetic variation within th...
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Article
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such ...
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Article
Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple stud...
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Article
Implication of European-derived adiposity loci in African Americans
Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Ameri...
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Article
Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort
Previous studies have replicated the association of variants within FTO (fat mass- and obesity-associated) intron 1 with obesity and adiposity quantitative traits in populations of European ancestry. Non-European...
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Article
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with a complex pathogenesis in which genetic, hormonal and environmental factors have a role. Rare mutations in the TREX1 gene, the major mam...
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Article
Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study
The majority of type 2 diabetes genome-wide association studies (GWAS) to date have been performed in European-derived populations and have identified few variants that mediate their effect through insulin res...
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Article
Erratum: Genetic associations of LYN with systemic lupus erythematosus
Correction to: Genes and Immunity (2009) 10, 397–403; doi:10.1038/gene.2009.19 Since the publication of the above paper, the authors and collaborators have identified the misspelling of the following collabora...
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Article
Erratum: Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing
Correction to: Genes and Immunity (2009) 10, 457–469; doi:10.1038/gene.2009.27 Since the publication of this paper, the authors have noticed that the functional region for SNPs rs4308977 and rs17616 in Table 1...
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Article
Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population
Systemic lupus erythematosus (SLE) is an autoimmune disease with highly variable clinical presentation. Patients suffer from immunological abnormalities that target T-cell, B-cell and accessory cell functions....
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Article
Identification of new SLE-associated genes with a two-step Bayesian study design
In our earlier study, we utilized a Bayesian design to probe the association of ∼1000 genes (∼10 000 single-nucleotide polymorphisms (SNPs)) with systemic lupus erythematosus (SLE) on a moderate number of trio...
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Article
Genetic associations of LYN with systemic lupus erythematosus
We targeted LYN, a src-tyosine kinase involved in B-cell activation, in case–control association studies using populations of European-American, African-American and Korean subjects. Our combined European-deri...
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Article
Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing
Genetic factors influence susceptibility to systemic lupus erythematosus (SLE). A recent family-based analysis in Caucasian and Chinese populations provided evidence for association of single-nucleotide polymo...
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Article
Evaluation of C1q genomic region in minority racial groups of lupus
Complement cascade plasma proteins play a complex role in the etiopathogenesis of systemic lupus erythematosus (SLE). Hereditary C1q deficiency has been strongly related to SLE; however, there are very few pub...
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Article
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)
This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American partic...
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Article
Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC
The ATP-binding cassette transporter (TAP) proteins are functionally relevant candidates for predisposition to systemic lupus erythematosus (SLE) by virtue of their role in autoantigen presentation and locatio...
