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Article
MKRN3 circulating levels in girls with central precocious puberty caused by MKRN3 gene mutations
MKNR3 is a paternally expressed gene whose mutations are the main cause of central precocious puberty (CPP). Protein circulating levels can be easily measured, as demonstrated in idiopathic CPP and healthy contro...
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Chapter and Conference Paper
High-Resolution Studies of Mass Transport Deposits: Outcrop Perspective for Understanding Modern Submarine Slope Failure and Associated Natural Hazards
Micro- to meso-scale outcrop studies on selected field analogues allow direct calibration and testing of geophysical interpretations performed on mass transport deposits in modern continental margins, in terms...
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Article
The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS)
Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impair...
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Article
A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study
The aim of this 52-week, open-label, non-inferiority trial was to compare the safety and efficacy of exenatide (an incretin mimetic) with that of biphasic insulin aspart.
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Article
40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Article
The relation of body fat mass and distribution to markers of chronic inflammation
OBJECTIVE: To study the relation of fibrinogen and C-reactive protein (CRP) to various measures of body fat and body fat distribution and to investigate whether these relations were explained by differences in in...
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Article
A serine/alanine polymorphism in the nucleotide-binding fold-2 of the sulphonylurea receptor-1 (S1369A) is associated with enhanced glucose-induced insulin secretion during pregnancy
The sulphonylurea receptor-1 (SUR-1) regulates glucose-induced insulin secretion by controlling K+-ATP channel activity of the pancreatic β-cell membrane. In this study, we investigated the putative role of a T/G...
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Article
Gastric emptying in Type II (non-insulin-dependent) diabetes mellitus before and after therapy readjustment: no influence of actual blood glucose concentration
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Article
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed Type II diabetes: the Insulin Resistance Atherosclerosis Study
Aims/hypothesis. Proinsulin concentrations are increased relative to insulin concentrations in subjects with Type II (non-insulin-dependent) diabetes mellitus. This could be secondary to hypergly...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
Differential expression of receptors for advanced glycation end products on monocytes in patients with IDDM
Accelerated modification of proteins by glucose terminating in the formation of advanced glycation endproducts (AGEs) is one of the main pathogenetic mechanisms of diabetes-associated complications. One pathw...
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Article
Autoantibodies to oxidised low density lipoproteins in IDDM are inversely related to metabolic control and microvascular complications
Diabetes mellitus is associated with an increased risk of atherosclerosis. The oxidation of low-density lipoproteins (LDL) is considered a key event in the initiation of atherosclerosis. To investigate LDL ox...
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Article
Insulin reduces HBsAg production by PLC/PRF/5 human hepatoma cell line
Although its action at the molecular level is not completely understood, insulin, as well as its antagonist glucagon, certaily plays an important role in the modulation of protein synthesis.
