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Article
Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
Central obesity, insulin resistance and beta cell dysfunction are independent risk factors for incident type 2 diabetes, although few studies have used detailed measures of these disorders. Our objective was t...
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Article
Risk of type 2 diabetes among individuals with high and low glomerular filtration rates
Metabolic abnormalities frequently develop prior to the diagnosis of type 2 diabetes and chronic kidney disease. However, it is not known whether GFR predicts the onset of type 2 diabetes.
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Article
Characteristics and prevalence of the metabolic syndrome among three ethnic groups in Canada
To compare the characteristics and prevalence of the metabolic syndrome (MetS) among Native Indians, Inuit, and non-Aboriginal Canadians.
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Article
Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population
To determine the prevalence of ‘hypertriglyceridemic waist’ (HTGW) in Oji-Cree, to examine its interaction with hepatic nuclear factor-1α (HNF1A) in association with type 2 diabetes, and to characterize its putat...
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Article
Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications
Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of develo** type 2 diabetes and thus provides an excellent model for studying early events in the natural history of th...
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Article
40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Article
Disparity between association and linkage analysis for HNF1A G319S in type 2 diabetes in Canadian Oji-Cree
In parallel experiments designed to find the genetic determinants of type 2 diabetes in Oji-Cree, we identified several linked chromosomal regions, using genomic scanning, in addition to a private diabetes-as...