9 Result(s)

Article

Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation

Mitochondrial DNA copy number (mtDNA-CN) measured from blood specimens is a minimally invasive marker of mitochondrial function that exhibits both inter-individual and intercellular variation. To identify gene...

R. J. Longchamps, S. Y. Yang, C. A. Castellani, W. Shi, J. Lane… in Human Genetics (2022)

Article

Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance

Insulin clearance is a highly heritable trait, for which few quantitative trait loci have been discovered. We sought to determine whether validated type 2 diabetes and/or glycaemic trait loci are associated wi...

M. O. Goodarzi, X. Guo, J. Cui, M. R. Jones, T. Haritunians, A. H. **ang… in Diabetologia (2013)

Article

The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS)

Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impair...

C. C. Lee, C. Lorenzo, S. M. Haffner, L. E. Wagenknecht, A. Festa… in Diabetologia (2013)

Article

Transferability and fine-map** of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource

Hyperglycaemia disproportionately affects African-Americans (AfAs). We tested the transferability of 18 single-nucleotide polymorphisms (SNPs) associated with glycaemic traits identified in European ancestry (...

C. -T. Liu, M. C. Y. Ng, D. Rybin, A. Adeyemo, S. J. Bielinski… in Diabetologia (2012)

Article

Erratum to: Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis

P. Wojciechowski, A. Lipowska, P. Rys, K. G. Ewens, S. Franks, S. Tan… in Diabetologia (2012)

Article

Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis

FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes. Several small studies have suggested a greater than expected ef...

P. Wojciechowski, A. Lipowska, P. Rys, K. G. Ewens, S. Franks, S. Tan… in Diabetologia (2012)

Article

Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis

We have previously documented a high heritability of insulin clearance in a Hispanic cohort. Here, our goal was to confirm the high heritability in a second cohort and search for genetic loci contributing to i...

X. Guo, J. Cui, M. R. Jones, T. Haritunians, A. H. **ang, Y.-D. I. Chen… in Diabetologia (2012)

Article

A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)

This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American partic...

S. S. Rich, M. O. Goodarzi, N. D. Palmer, C. D. Langefeld, J. Ziegler… in Diabetologia (2009)