A Practical Guide to Metabolomics Applications in Health and Disease
From Samples to Insights into Metabolism
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Julijana Ivanisevic
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Open AccessMolecular insights into sex-specific metabolic alterations in Alzheimer’s mouse brain using multi-omics approach
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by altered cellular metabolism in the brain. Several of these alterations have been found to be exacerbated in females...
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Chapter
Introduction
Metabolite identification and quantification have been instrumental to advances in biochemistry and biology. Over centuries, technological advances have been going hand in hand with biochemical/biological pro...
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Book
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A Lipidome-Wide Association Study: Data Processing, Annotation, and Analysis Workflow Using MS-DIAL and R
This section provides the theoretical background on metabolic phenoty** and its application to human research. We highlight major determinants of the serum lipid composition and describe the principles of ma...
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Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse ske...
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Article
Open AccessA combination of plasma membrane sterol biosynthesis and autophagy is required for shade-induced hypocotyl elongation
Plant growth ultimately depends on fixed carbon, thus the available light for photosynthesis. Due to canopy light absorption properties, vegetative shade combines low blue (LB) light and a low red to far-red r...
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Open AccessGut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia
Most cancer cells have high need for nicotinamide adenine dinucleotide (NAD+) to sustain their survival. This led to the development of inhibitors of nicotinamide (NAM) phosphoribosyltransferase (NAMPT), the rate...
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Open AccessThe Metabolic Signature of Cardiorespiratory Fitness: A Systematic Review
Cardiorespiratory fitness (CRF) is a potent health marker, the improvement of which is associated with a reduced incidence of non-communicable diseases and all-cause mortality. Identifying metabolic signatures...
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PERK is a critical metabolic hub for immunosuppressive function in macrophages
Chronic inflammation triggers compensatory immunosuppression to stop inflammation and minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress augments the suppressive phenotype...
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Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity
Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting tumor progression in response to microenvironmental cues imposed by tumor and stromal cells. However, the underlying mechan...
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Central anorexigenic actions of bile acids are mediated by TGR5
Bile acids (BAs) are signalling molecules that mediate various cellular responses in both physiological and pathological processes. Several studies report that BAs can be detected in the brain1, yet their physiol...
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Article
Open AccessDBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies
As a powerful phenoty** technology, metabolomics provides new opportunities in biomarker discovery through metabolome-wide association studies (MWAS) and the identification of metabolites having a regulatory...
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Open AccessAuthor Correction: Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessMechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models
Understanding the adaptive responses of individual bacterial strains is crucial for microbiome engineering approaches that introduce new functionalities into complex microbiomes, such as xenobiotic compound me...
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Article
Open AccessSystemic and central nervous system metabolic alterations in Alzheimer’s disease
Metabolic alterations, related to cerebral glucose metabolism, brain insulin resistance, and age-induced mitochondrial dysfunction, play an important role in Alzheimer’s disease (AD) on both the systemic and c...
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Identification of bioactive metabolites using activity metabolomics
The metabolome, the collection of small-molecule chemical entities involved in metabolism, has traditionally been studied with the aim of identifying biomarkers in the diagnosis and prediction of disease. Howe...
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De novo NAD+ synthesis enhances mitochondrial function and improves health
Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased NAD+ levels and sirtuin activatio...
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XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules
We report XCMS-MRM and METLIN-MRM (http://xcmsonline-mrm.scripps.edu/ and http://metlin.scripps.edu/), a cloud-based data-analysis platform and a public multiple-reaction monitoring (MRM) transition repository fo...
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Metabolomics as a Tool to Understand Pathophysiological Processes
Multiple diseases have a strong metabolic component, and metabolomics as a powerful phenoty** technology, in combination with orthogonal biological and clinical approaches, will undoubtedly play a determinan...
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Article
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.
