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  1. No Access

    Article

    Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

    Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse ske...

    Pirkka-Pekka Laurila, Martin Wohlwend, Tanes Imamura de Lima, Peiling Luan… in Nature Aging (2022)

  2. Article

    Open Access

    Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

    Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but no...

    Nadège Zanou, Haikel Dridi, Steven Reiken, Tanes Imamura de Lima… in Nature Communications (2021)

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