-
Article
Open AccessSMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation
In obesity, adipose tissue undergoes a remodeling process characterized by increased adipocyte size (hypertrophia) and number (hyperplasia). The ability to tip the balance toward the hyperplastic growth, with ...
-
Article
Open AccessCannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study
Association between cannabis use and development of atherosclerotic cardiovascular disease (ASCVD) is inconsistent and challenging to interpret, given existing study limitations.
-
Article
Open AccessRandomly controlled drivers using minimally invasive sampling: assessment of drug prevalence in Western Switzerland over two time periods
According to the World Health Organization, road traffic injuries lead to 1.3 million deaths each year and represent the leading cause of death for young adults under 30 years old. The use of psychoactive subs...
-
Article
Open AccessA single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
Regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (BDNF) levels. Likewise, short periods of exercise, or acute exercise, benefit...
-
Article
Open AccessTriangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes
The number of people affected by Type 2 diabetes mellitus (T2DM) is close to half a billion and is on a sharp rise, representing a major and growing public health burden. Given its mild initial symptoms, T2DM ...
-
Article
Open AccessDBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies
As a powerful phenoty** technology, metabolomics provides new opportunities in biomarker discovery through metabolome-wide association studies (MWAS) and the identification of metabolites having a regulatory...
-
Article
Open AccessDetecting early myocardial ischemia in rat heart by MALDI imaging mass spectrometry
Diagnostics of myocardial infarction in human post-mortem hearts can be achieved only if ischemia persisted for at least 6–12 h when certain morphological changes appear in myocardium. The initial 4 h of ische...
-
Chapter and Conference Paper
Design of an 8-DoF Redundant Robotic Platform for Medical Applications
Redundant robots can provide improved kinematic performances compared to non-redundant robots, becoming suitable to perform complex tasks in several areas of application. Improved manipulability or dexterity a...
-
Article
Open AccessAnti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue
Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms in...
-
Article
Open AccessEffect of acute physical exercise on motor sequence memory
Acute physical exercise improves memory functions by increasing neural plasticity in the hippocampus. In animals, a single session of physical exercise has been shown to boost anandamide (AEA), an endocannabin...
-
Article
Phenoty** of Human CYP450 Enzymes by Endobiotics: Current Knowledge and Methodological Approaches
Drug response is subject to an important within- and between-individual variability owing, mainly, to pharmacokinetic and pharmacodynamic factors. Pharmacokinetics includes metabolism by cytochrome P450 (CYP45...
-
Article
Multiplex quantitative imaging of human myocardial infarction by mass spectrometry-immunohistochemistry
Simultaneous assessment of a panel of protein markers is becoming essential in order to enhance biomarker research and improve diagnostics. Specifically, postmortem diagnostics of early myocardial ischemia in ...
-
Article
XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules
We report XCMS-MRM and METLIN-MRM (http://xcmsonline-mrm.scripps.edu/ and http://metlin.scripps.edu/), a cloud-based data-analysis platform and a public multiple-reaction monitoring (MRM) transition repository fo...
-
Protocol
Metabolomics as a Tool to Understand Pathophysiological Processes
Multiple diseases have a strong metabolic component, and metabolomics as a powerful phenoty** technology, in combination with orthogonal biological and clinical approaches, will undoubtedly play a determinan...
-
Article
Open AccessIn vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system
Direct collection of extracellular fluid (ECF) plays a central role in the monitoring of neurological disorders. Current approaches using microdialysis catheters are however drastically limited in term of temp...
-
Article
Imaging mass spectrometry of elements in forensic cases by LA-ICP-MS
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was performed to map elements in thin formalin-fixed paraffin-embedded tissue sections of two forensic cases with firearm and electrocuti...
-
Chapter
Omics in Forensic Toxicology a Bridge Towards Forensic Medicine
Cutting-edge omic strategies are bringing new opportunities to many fields of investigation from the biomedical to the biomedicolegal. Comprehension of molecular mechanisms associated with pathologies such as ...
-
Article
Open AccessAssessment of pathological response to therapy using lipid mass spectrometry imaging
In many cancers, the establishment of a patient’s future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the ‘pathological response’ ...
-
Article
Open AccessDrug va** applied to cannabis: Is “Cannava**” a therapeutic alternative to marijuana?
Therapeutic cannabis administration is increasingly used in Western countries due to its positive role in several pathologies. Dronabinol or tetrahydrocannabinol (THC) pills, ethanolic cannabis tinctures, orom...
-
Chapter
(MA)LDI MS Imaging at High Specificity and Sensitivity
(Matrix-assisted) laser desorption/ionization ((MA)LDI) mass spectrometry imaging (MSI) has been driven by remarkable technological developments in the last couple of years. Although molecular information of a...
