-
Article
Targeting ferroptosis by natural products in pathophysiological conditions
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement of ferroptosis in different pathophysiological conditions has offered new perspectives o...
-
Article
Open AccessHigh-content image screening to identify chemical modulators for peroxisome and ferroptosis
The peroxisome is a dynamic organelle with variety in number, size, shape, and activity in different cell types and physiological states. Recent studies have implicated peroxisomal homeostasis in ferroptosis s...
-
Article
The interplay of miRNAs and ferroptosis in diseases related to iron overload
Ferroptosis has been conceptualized as a novel cell death modality distinct from apoptosis, necroptosis, pyroptosis and autophagic cell death. The sensitivity of cellular ferroptosis is regulated at multiple l...
-
Article
Open AccessFunctional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Macrophages are highly plastic in different tissues and can differentiate into functional subpopulations under different stimuli. Tumor-associated macrophages (TAMs) are one of the most important innate immune...
-
Article
Open AccessAuthor Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions
-
Article
Open AccessCD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions
Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization accompanied by metabolic reprogramming, characterized by elevated aerobic glycolysis and a broken tricarboxylic acid cycle. Howe...
-
Article
PERK is a critical metabolic hub for immunosuppressive function in macrophages
Chronic inflammation triggers compensatory immunosuppression to stop inflammation and minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress augments the suppressive phenotype...
-
Article
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic insufficie...
-
Protocol
Determining Macrophage Polarization upon Metabolic Perturbation
Metabolic reprograming controlling macrophage activation and function is emerging as new regulatory circuit on sha** immune responses. Generally, lipopolysaccharides (LPS)-induced pro-inflammatory activated ...
-
Article
Open AccessGlyburide and retinoic acid synergize to promote wound healing by anti-inflammation and RIP140 degradation
Chronic inflammation underlies the development of metabolic diseases and individuals with metabolic disease often also suffer from delayed wound healing due to prolonged inflammation. Resolving inflammation pr...
-
Article
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.
-
Article
Open AccessMetabolic communication in tumors: a new layer of immunoregulation for immune evasion
The success of cancer immunotherapy reveals the power of host immunity on killing cancer cells and the feasibility to unleash restraints of anti-tumor immunity. However, the immunosuppressive tumor microenviro...
